Skin Hyperpigmentation in Complex Regional Pain Syndrome
April 2015
in “
Neurology
”
TLDR Skin pigmentation increases in CRPS-affected areas and improves with symptom relief.
The study aimed to characterize hyperpigmented skin changes in limbs affected by Complex Regional Pain Syndrome (CRPS). It found that skin pigmentation increased in areas with CRPS symptoms, such as swelling and altered hair growth, and also in mirror-image locations on opposite limbs. Unlike Schamberg’s purpura, these pigmentation changes improved with the alleviation of CRPS symptoms, suggesting a neurogenic or humoral mechanism. The study highlighted the importance of recognizing these skin manifestations for early diagnosis and treatment of CRPS.