Skin Hyperpigmentation in Complex Regional Pain Syndrome

    April 2015 in “ Neurology ”
    Robert Knobler
    TLDR Skin pigmentation increases in CRPS-affected areas and improves with symptom relief.
    The study aimed to characterize hyperpigmented skin changes in limbs affected by Complex Regional Pain Syndrome (CRPS). CRPS is a challenging neuropathic pain syndrome with subjective symptoms like burning pain, making early diagnosis difficult. The study found that skin pigmentation increased in areas with CRPS symptoms, such as swelling and altered hair growth, and also in mirror-image locations on opposite limbs. Unlike Schamberg’s purpura, these pigmentation changes improved with the alleviation of CRPS symptoms, suggesting a neurogenic or humoral mechanism. The study did not receive external support, and Dr. Knobler disclosed compensation from pharmaceutical companies.
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