January 2024 in “Scientific reports” This study found that undiluted mint leaf extract effectively inhibited multidrug-resistant Staphylococcus aureus and killed Culex pipiens larvae, suggesting its potential as a biocontrol strategy around hospitals.
January 2024 in “Journal of the Endocrine Society” In this study, correlations between urinary and serum androgen metabolites were examined in girls aged 6-13, revealing that summed urinary metabolites strongly correspond with circulating androstenedione and testosterone levels, though individual variations depend on participant characteristics such as age and body measurements.
August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that maintaining a low level of Wnt/β-catenin activity is crucial for mammary gland development, as excessive activity inhibits branching and promotes characteristics of hair follicles instead, highlighting its role in skin appendage identity decisions.
This case report describes a 14-year-old girl with coeliac disease who presented with severe hypercalcaemia due to a parathyroid adenoma, which resolved after its excision.
July 2011 in “British Journal of Dermatology” Dermatologists give better information on pathology forms, hypersensitivity vasculitis is a common skin issue, misdiagnoses can occur, and various skin conditions are linked to loss of elastin or genetic factors.
This article reviews the synthesis and properties of isotretinoin, tazarotene, minoxidil, and finasteride, and reports no new findings.
October 1999 in “The Journal of Urology” This article discusses developments in clinical urology featured in the Journal of Urology's October 1999 issue and presents no new clinical findings.
May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, primary cilia were found to contribute to meibomian gland enlargement and lipid production, though they are not necessary for normal gland development.
January 2021 in “ABC Heart Failure & Cardiomyopathy” This case report describes a 90-year-old man diagnosed with wild-type transthyretin cardiac amyloidosis, confirmed by pyrophosphate cardiac scintigraphy and exclusion of gene mutations.
February 1999 in “Drugs in R & D” The document concludes that various drugs for men's health issues are in development, with treatments for sexual dysfunction and prostate conditions being the most advanced.
13 citations
,
February 2015 in “Actas Dermo-Sifiliográficas” This review discusses the histologic features of nonscarring alopecia and highlights the importance of clinical-pathological correlation for accurate diagnosis, but reports no new clinical results.
14 citations
,
June 2015 in “Toxicology and Industrial Health” This study found that low doses of bisphenol A may increase proliferation of the ventral prostate in adult rats by altering the estrogen to androgen ratio and gene expression.
16 citations
,
September 2014 in “International Journal of Biological Markers” This study found that the less common CAG-rs4045402 and GGN-rs3138869 polymorphisms were more frequent in patients with post-finasteride syndrome and androgenetic alopecia, suggesting a genetic predisposition to AGA development.
3 citations
,
April 2019 in “Human & Experimental Toxicology” This study found that finasteride caused adverse effects on liver, kidney, and heart tissues in female mice, raising concerns about its potential use in females for treating androgenetic alopecia.
7 citations
,
January 2011 in “Veterinary Pathology” In this case report, a 9-year-old horse was diagnosed with alopecia areata contributing to Malassezia dermatitis, involving lymphocyte infiltration and symptoms consistent with yeast presence.
60 citations
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January 1989 in “Toxicologic Pathology” This paper discusses the pathogenesis of cardiovascular lesions in dogs associated with minoxidil, noting that lesions were not prevented by adrenergic blockade or neural activity suppression, and highlights the differences in injury progression between coronary arteries and the right atrium.
5 citations
,
March 2015 in “Women's Health” This article reviews the process for diagnosing polycystic ovary syndrome and suggests how it can be applied in clinical practice but reports no new results.
5 citations
,
March 2013 in “International journal of surgical pathology” This case report illustrates that a diagnosis of Cronkhite-Canada syndrome can be made without the presence of polyps, as demonstrated by resolving symptoms with steroid treatment.
3 citations
,
September 2019 in “American Journal of Men's Health” This study suggests that continuing finasteride therapy after mastectomy does not significantly affect gynecomastia recurrence in men taking finasteride for alopecia.
3 citations
,
April 2019 in “Journal of psychosexual health” This review discusses the psychiatric and sexual comorbidities of PCOS, emphasizing the need for a multidisciplinary approach to manage sexual dysfunction due to high prevalence rates found in recent studies.
3 citations
,
September 2016 in “Natural Product Communications” This study identified 8-hydroxy germacrene B from Curcuma aeruginosa as a highly potent in-vitro 5-alpha reductase inhibitor with significant anti-androgenic activity, while exhibiting mild cytotoxicity on prostate cancer cells without affecting human dermal papilla cells at tested concentrations.
10 citations
,
January 2010 in “Veterinary pathology” This study found that a newly identified mutation in the hairless gene in mice led to decreased Hr mRNA levels and changes in gene expression related to hair follicle development.
61 citations
,
May 2010 in “Integrative Cancer Therapies” This review discusses the potential benefits and risks of selenium in cancer prevention and treatment, emphasizing that while selenium may offer advantages for tumor patients, further research is needed due to mixed findings regarding diabetes risk.
38 citations
,
December 2009 in “Therapeutic Advances in Medical Oncology” This discussion proposes a model to incorporate patients with hormone-resistant prostate cancer into the existing framework by redefining hormone resistance and exploring new therapeutic approaches.
21 citations
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January 2021 in “Therapeutic Advances in Endocrinology and Metabolism” The researchers suggest that testosterone levels might influence COVID-19 susceptibility and severity, with low levels potentially protecting against infection but possibly worsening severe disease due to cytokine storm activation.
19 citations
,
March 2007 in “Journal of diabetes science and technology” This study found that both metformin and rosiglitazone improved ovulation and insulin sensitivity in women with PCOS, with rosiglitazone showing a more pronounced increase in adiponectin levels.
19 citations
,
October 1994 in “Tumori Journal” This review discusses the current medical treatments for hepatocellular carcinoma, noting that while new local therapies show high response rates, their true impact on patient survival is uncertain.
13 citations
,
June 2018 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” This study found that the expression of laminin-511 and -332 was significantly increased in psoriasis skin lesions and may influence keratinocyte proliferation and apoptosis, suggesting a previously overlooked role in the disease's pathogenesis.
10 citations
,
January 2017 in “Journal of Evidence-Based Complementary & Alternative Medicine” This study found that several local vegetables from Northern Thailand demonstrated significant antioxidant and 5α-reductase inhibitory activities, suggesting their potential for development into health-promoting products.
6 citations
,
August 2014 in “Toxicologic pathology” This study found that prolonged inhibition of DGAT1 in mice and dogs led to atrophy of sebaceous glands, with mice also experiencing alopecia, suggesting potential skin-related risks for humans using DGAT1 inhibitors.