April 2020 in “Rice Research Repository (Rice University)” This study suggests that MultiDomain Peptide hydrogels may support wound healing in diabetic mice by accelerating closure and promoting tissue regeneration, though they did not inhibit bacterial growth in infected wounds as expected.
September 2026 in “Mendeley Data” This study found that the polyurethane-cellulose acetate scaffold containing plasma rich in growth factors enhanced gene expression linked to wound healing compared to controls.
54 citations
,
November 1994 in “Differentiation” This study found that trichohyalin is expressed in various normal and pathological epithelia beyond hair follicle cells, where it is uniquely associated with filaggrin, suggesting a specific role in aggregating K6/K16-containing intermediate filaments.
36 citations
,
January 1994 in “Cell and Tissue Research” January 2025 in “International Journal of Trichology” This case study reported transient localized hypertrichosis in a 26-year-old woman following cast removal from a forearm fracture, which resolved on its own after 5 months, suggesting that similar incidents of hair growth after trauma may have a benign and temporary course.
In this study, researchers developed a multifunctional hydrogel for wound healing, incorporating antibacterial and antioxidant properties that demonstrated significant inflammation reduction and tissue regeneration in animal models, with high antibacterial efficacy against E. coli and S. aureus.
4 citations
,
November 2024 in “BMC Ophthalmology” This case report describes a rare instance of a giant and atypical proliferating pilomatrixoma on the eyelid, successfully treated with surgical excision, with no recurrence observed after one year, emphasizing the need to excise and histologically evaluate enlarging periocular masses to rule out malignancy.
7 citations
,
July 2016 in “Journal of Biomedical Materials Research Part A” This study found that a novel hydrogel scaffold, cGEL, significantly increased melanin production and melanotic gene expression in human melanocytes compared to other graft materials, suggesting its potential as a superior carrier for skin grafting.
7 citations
,
March 2014 in “ISRN Biomaterials” In this study, a keratin hydrogel improved survival rates and functional recovery in rats with spinal cord injuries, suggesting potential for SCI treatment that merits further investigation.
August 1978 in “Archives of Dermatology” This case report details a rare instance of granulomatosis disciformis chronica et progressiva affecting both skin and lymph node tissue in a 31-year-old man.
March 2025 in “Journal of Burn Care & Research” In this study, the hemostatic net was associated with 100% integration of non-meshed partial-thickness skin grafts without seroma or hematoma in treated burn areas after 21 days.
August 2025 in “Acta Biomaterialia” This study presents a novel hydrogel scaffold made from tilapia collagen, which when activated by ultrasound, reprograms macrophages to promote wound healing, enhance angiogenesis, and stimulate hair follicle regeneration, offering a potential new method for treating inflammatory wounds.
27 citations
,
October 2020 in “Biomedicine & Pharmacotherapy” This study found that transplanting hair follicle bulge-derived stem cells in rats enhanced skin regeneration during expansion by differentiating into several skin-related cells and increasing the expression of growth factors.
1 citations
,
April 2021 in “Journal of Investigative Dermatology” This study found that laboratory and African spiny mice have distinct spatiotemporal patterns in wound-induced hair neogenesis, with the Twist1 pathway playing a central role in epidermal-dermal interactions for hair primordia formation.
11 citations
,
January 2019 in “Dermatologic Surgery” In this study, hair follicle transplantation into nonhealing ulcers promoted rapid wound closure, with differing scar quality and hair growth between the central and peripheral wound areas.
January 2012 in “Institutional Repositories DataBase (IRDB)” This study observed that cell aggregates derived from mouse skin and lung tissues may aid in hair follicle regeneration when transplanted into skin defects of immunodeficient mice.
1 citations
,
July 2009 in “Journal of dermatology” This case report describes a 29-year-old Japanese man with follicular mucinosis, suggesting nestin-positive, multipotent hair follicle stem cells may be involved in reticular epithelial degeneration of the outer root sheath.
March 2026 in “South Asian Research Journal of Medical Sciences” In this case study, a 7-year-old boy with kerion celsi experienced persistent inflammation even after microbiological clearance; dermoscopic-guided removal of hair and keratin debris improved his condition, suggesting a novel inflammatory mechanism involving granulomatous response to keratinous debris in tinea capitis.
8 citations
,
January 2024 in “Journal of Materials Chemistry B” In this study, acellular dermal matrix hydrogels significantly improved healing in a rat model of radiation-induced skin injury by promoting angiogenesis and modulating inflammation, suggesting potential as a novel treatment for this common radiotherapy complication.
254 citations
,
March 2023 in “Advanced Science” This study developed an all-natural hydrogel that promotes diabetic wound healing by converting pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophages in a simple and biosafe manner.
August 1998 in “Dermatologic Surgery” Use steroid creams without parabens and educate on hair transplant techniques to improve cosmetic surgery outcomes.
12 citations
,
November 2023 in “Tissue Engineering and Regenerative Medicine”
15 citations
,
March 2012 in “International journal of nanomedicine” In this study, local injection of nanosized recombinant human erythropoietin at the injury site improved skin regeneration and re-epithelialization in a mouse model of deep second-degree burns through coexpression of specific receptors.
3 citations
,
January 1989 in “The Nishinihon Journal of Dermatology” This case report describes a proliferating trichilemmal cyst that underwent malignant transformation, with specific keratins identified in the tumor but no epidermal keratin detected.
147 citations
,
April 1997 in “Oncogene” This study found that transgenic mice expressing IGF-1 in their skin showed significant skin changes, early hair follicle generation, and a higher propensity to develop tumors after chemical promotion, suggesting IGF-1's role in skin carcinogenesis.
26 citations
,
April 2012 in “PubMed” In this study, myofibroblasts in rat cutaneous fibrosis were characterized by expressions of vimentin, α-SMA, and Thy-1, and may derive from pericytes or perifollicular dermal sheath cells.
3 citations
,
January 1985 in “Acta Obstetricia Et Gynecologica Scandinavica” This case study describes a rare instance of a Granulosa‐Theca cell tumor causing sexual precocity in a 12-month-old infant, with significantly reduced estradiol levels following tumor removal.
68 citations
,
March 2018 in “Biomaterials” This study found that fibronectin nanofiber dressings, made using rotary jet spinning, accelerated wound healing and improved tissue restoration in a full-thickness wound mouse model.
August 2023 in “Journal of Investigative Dermatology” Skin organoids can regenerate hair by forming specific cell units with certain signals.
9 citations
,
March 2023 in “Biomimetics” This review discusses current strategies and materials in tissue engineering for skin regeneration, emphasizing design approaches and suggesting directions for future research; it reports no new clinical findings.