Granulosa-Theca Cell Tumor in a One-Year-Old Infant
January 1985
in “
Acta Obstetricia Et Gynecologica Scandinavica
”
New to Estradiol? There is a guide in the encyclopedia. Read the guide → Studysummary This case study describes a rare instance of a Granulosa‐Theca cell tumor causing sexual precocity in a 12-month-old infant, with significantly reduced estradiol levels following tumor removal.
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A case study from 1985 described a 12-month-old female infant with sexual precocity caused by a Granulosa-Theca cell tumor, which led to symptoms such as vaginal bleeding, breast development, and pubic hair growth. The infant's 17β-estradiol levels were significantly elevated at 300 pg/ml before surgery, with undetectable gonadotropin levels. After the tumor was surgically removed, estradiol levels dropped to 10 pg/ml. This type of tumor was extremely rare in infants, with only four other cases reported in children under 2 years of age at that time.
