Granulosa-Theca Cell Tumor in a One-Year-Old Infant

    January 1985 in “ Acta Obstetricia Et Gynecologica Scandinavica ”
    Joseph B. Lessing, M Michowitz, M Baratz
    TLDR A rare ovarian tumor caused early puberty signs in a 1-year-old girl, but surgery reduced hormone levels.
    A case study from 1985 described a 12-month-old female infant with sexual precocity caused by a Granulosa-Theca cell tumor, which led to symptoms such as vaginal bleeding, breast development, and pubic hair growth. The infant's 17β-estradiol levels were significantly elevated at 300 pg/ml before surgery, with undetectable gonadotropin levels. After the tumor was surgically removed, estradiol levels dropped to 10 pg/ml. This type of tumor was extremely rare in infants, with only four other cases reported in children under 2 years of age at that time.
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