May 2026 in “Endocrine Connections” This review posits that alopecia in PCOS results from the interaction between local follicular signaling failures, insulin resistance, inflammation, and genetic predispositions, rather than solely from androgen excess, and recommends a systems-level framework for its management.
1 citations
,
January 1989 in “Handbook of experimental pharmacology” This article reviews the use of anti-androgens for dermatological conditions linked to androgen involvement and reports encouraging clinical experiences in females, with use in males limited to specific conditions due to toxicity concerns.
4 citations
,
April 2002 in “Medical Hypotheses” Hormones cause hair loss by affecting cell growth and weakening cell attraction.
11 citations
,
January 1991 in “Urology” This article reviews the potential of combining antiandrogenic and antiestrogenic treatments for BPH, highlighting aromatase inhibitors, but presents no new clinical results; further research is needed.
This study found that metabolic syndrome is more common in individuals with androgenic alopecia compared to those without, and that free androgen index could help identify those with the syndrome.
October 2007 in “Postgraduate obstetrics & gynecology” This article reviews the unapproved use of testosterone for treating female androgen insufficiency and reports no new clinical results.
January 2002 in “Actas Dermo-Sifiliográficas” This case study reports a 72-year-old woman developed male-pattern baldness after self-medicating with a high-content androgenic supplement for over 30 years.
26 citations
,
March 2009 in “Dermato-endocrinology” This review discusses the evaluation, clinical presentation, and cutaneous manifestations of congenital adrenal hyperplasia, focusing on differential diagnosis challenges with polycystic ovary syndrome, and reports no new clinical findings.
32 citations
,
January 1990 in “Clinical Endocrinology” This study found that women with female pattern androgenic alopecia have significantly higher levels of certain androgens and androgen sulfates compared to normal premenopausal women, suggesting markers for diagnosis and treatment efficacy.
October 2020 in “Проблемы эндокринологии” This review discusses the potential roles of androgens and antiandrogens in COVID-19 outcomes, noting unresolved questions about their effectiveness and safety for treatment.
This study found that cell strains overexpressing the androgen receptor proliferated better in low or no DHT conditions and translocated AR more efficiently than control strains.
April 2014 in “Acta Medica Colombiana” This study presents a 63-year-old man with uncontrolled hypertension and facial hair who was diagnosed with adrenocortical adenoma, and whose blood pressure improved post-surgery.
6 citations
,
September 2005 in “Expert Opinion on Pharmacotherapy” This review discusses the role of androgens in women's sexual health and highlights the need for further research on androgen replacement therapy to optimize quality of life, but reports no new clinical results.
7 citations
,
October 2012 in “S. Karger AG eBooks” This review discusses the similarities in clinical, endocrine, and ultrasonographic features between PCOS and other disorders with excessive androgen secretion, emphasizing the importance of accurate diagnosis but reports no new clinical results.
September 2023 in “Journal of the European Academy of Dermatology and Venereology” This letter discusses the potential of the "Gabrin sign" as an indicator for identifying high-risk COVID-19 patients with androgenic alopecia, yet no specific results are detailed in the text.
56 citations
,
August 2005 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses the complex interaction between androgens and hair follicle biology, highlighting the need for a better understanding to improve hirsutism treatments, but reports no new results.
August 2023 in “The American Journal of the Medical Sciences” This study found that men with androgenetic alopecia had higher serum uric acid levels and a greater incidence of hyperuricemia compared to those without, but finasteride treatment significantly reduced uric acid levels over six months.
2 citations
,
April 2013 in “Expert Review of Endocrinology & Metabolism” This review discusses the challenges in diagnosing different causes of adult androgen excess and outlines current screening and management strategies but reports no new findings.
11 citations
,
August 2000 in “Journal of Endocrinology” In this study, treatment with DHEA induced mild to moderate hyperplasia of sebaceous glands in ovariectomized rats, which was prevented by the antiandrogen Flutamide but not by the antiestrogen EM-800.
December 2022 in “Biomedicine” This study found that men with early onset androgenetic alopecia often have higher serum uric acid levels and an increased prevalence of hyperuricemia compared to controls.
June 2023 in “Journal of Liaquat University of Medical & Health Sciences” This study observed that women with PCOS from Khyber Pakhtunkhwa had significantly higher serum PSA levels, which positively correlated with hirsutism, testosterone, and DHEAS levels compared to healthy controls.
April 2019 in “Journal of the Endocrine Society” This report describes an exceptionally rare adrenal neoplasm in a post-menopausal woman that exclusively secreted DHEA-S, with significant serum level reduction following adrenalectomy.
December 2016 in “University of Birmingham Institutional Research Archive (University of Birmingham)” In this study, using a 3D culture model, researchers observed that developmental stage and androgen levels influenced murine follicle growth, which may inform treatment for women with low ovarian reserve but cautions against excessive androgen exposure.
April 2021 in “Journal of evolution of medical and dental sciences” This study found that bioavailable testosterone and the free androgen index were significantly associated with various clinical and biochemical features of PCOS, including hirsutism, showing higher levels in PCOS patients compared to controls.
2 citations
,
January 2012 in “Journal of metabolic syndrome” This review summarizes current knowledge on the diagnosis and treatment of hirsutism but provides no new clinical results.
1 citations
,
August 2022 in “Case Reports” This case report describes a woman in her 30s who had virilisation and androgenic alopecia due to a testosterone-secreting ovarian tumor, which normalized after its surgical removal.
February 2010 in “Journal of The American Academy of Dermatology” This review examines microbial production and applications of gluconic acid, focusing on the enzymatic processes involved, and offers no new experimental results.
14 citations
,
September 2015 in “Expert Opinion on Therapeutic Targets” This review discusses potential treatments for androgen excess in polycystic ovary syndrome and reports no new findings, emphasizing the importance of individualized antiandrogenic management to minimize side effects.
May 2024 in “Research Square (Research Square)” In this retrospective study from Jiangsu Province Hospital, researchers reported a high prevalence of pediatric androgenetic alopecia in patients under 18, often associated with hormonal imbalances and comorbid conditions, emphasizing the need for individualized treatment plans that prioritize addressing hormonal disorders and comorbidities.
36 citations
,
April 2011 in “Journal of The American Academy of Dermatology” People with hair loss have higher risk of high blood sugar and diabetes, and lower levels of a specific hormone.