Relationship of Serum Prostate-Specific Antigen with Hirsutism in Women with Polycystic Ovary Syndrome in Khyber Pakhtunkhwa, Pakistan

June 2023 in “ Journal of Liaquat University of Medical & Health Sciences ”

Naheed Khattak, Sadaf Durrani, Sobia Ali, Kalsoom Tariq, Ubaid ur Rahman, Ahmed Khan

prostate-specific antigen hirsutism polycystic ovary syndrome testosterone DHEAS PSA PCOS dehydroepiandrosterone sulfate

The study investigated the relationship between serum prostate-specific antigen (PSA) and hirsutism in women with polycystic ovary syndrome (PCOS) in Khyber Pakhtunkhwa, Pakistan. Conducted from June to December 2021, it involved 172 participants, with 86 newly diagnosed PCOS cases and 86 healthy controls. Results showed significantly higher serum PSA levels in PCOS females (0.325±0.243 vs. 0.119±0.209, P <0.0001), along with increased testosterone and DHEAS levels. A strong positive correlation was found between PSA and hirsutism, as well as with testosterone and DHEAS levels. The study concluded that elevated PSA is significantly associated with hirsutism in PCOS women.

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Research cited in this study

12 / 12 results

research Hirsutism, Normal Androgens, and Diagnosis of PCOS

63 citations , August 2022 in “Diagnostics”

research Serum Prostate Specific Antigen Levels in Women with Androgenetic Alopecia

April 2019 in “Turkderm”

Women with androgenetic alopecia (hair loss) have normal prostate specific antigen levels but higher testosterone levels.

research The Modified Ferriman-Gallwey Score and Hirsutism Among Filipino Women

22 citations , January 2019 in “Endocrinology and metabolism”

An mFG score of 7 or higher indicates hirsutism in Filipino women, often linked to higher free testosterone levels.

research Comprehensive Overview of Polycystic Ovary Syndrome

883 citations , August 2016 in “Nature Reviews Disease Primers”

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

research Hirsutism in Polycystic Ovary Syndrome: Pathophysiology and Management

47 citations , July 2016 in “Current pharmaceutical design”

The document concludes that managing hirsutism in PCOS involves long-term treatment guided by severity, using oral contraceptives and possibly antiandrogens, with attention to individual patient needs.

research Prostate Specific Antigen in Diagnosis of Polycystic Ovarian Syndrome: A New Insight

6 citations , July 2016 in “Gynecological Endocrinology”

PSA levels are higher in women with PCOS, but FAI is a more accurate marker for diagnosis.

research Serum Prostate Specific Antigen Level in Women with Polycystic Ovary Syndrome

1 citations , July 2016 in “Mağallaẗ Kulliyyaẗ al-ṭibb Baġdād”

Women with PCOS have higher PSA levels, which are linked to increased male hormone levels and hirsutism.

research Prostate-Specific Antigen as a Marker of Hyperandrogenism in Women and Its Implications for Antidoping

8 citations , June 2016 in “Clinical Chemistry”

PSA levels could help detect illegal steroid use in female athletes but face challenges like cost and PCOS prevalence.

research Polycystic Ovary Syndrome: Etiology, Pathogenesis, and Diagnosis

991 citations , January 2011 in “Nature Reviews Endocrinology”

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

research Visually Scoring Hirsutism

288 citations , June 2009 in “Human reproduction update”

The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.

research Androgens and Hair Growth

209 citations , September 2008 in “Dermatologic Therapy”

Androgens can both increase and decrease hair growth in different parts of the body.

research Is Prostate-Specific Antigen a Potential New Marker of Androgen Excess in Polycystic Ovary Syndrome?

16 citations , April 2007 in “Journal of Obstetrics and Gynaecology Research”

Prostate-specific antigen may be a new marker for excess male hormones in women with polycystic ovary syndrome.

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research Relationship of Serum Prostate-Specific Antigen with Hirsutism in Women with Polycystic Ovary Syndrome in Khyber Pakhtunkhwa, Pakistan

June 2023 in “Journal of Liaquat University of Medical & Health Sciences”