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Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Finasteride treatment changes Cx43 in rat testes, possibly causing fertility issues.

Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

The document explains how male reproductive hormones work and affect the body.

Spironolactone use is not linked to an increased risk of breast cancer, but caution is advised for high-risk patients.

A woman's skin symptoms led to a diagnosis of systemic AL amyloidosis, but she died from sepsis shortly after.

Certain skin diseases are linked to Agent Orange and similar chemicals; veterans should be screened and informed about uncertain risks, and current data doesn't link spironolactone with breast cancer.

Men and women experience skin aging differently due to changes in sex hormone levels with age.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Cortisone and cortisol levels in pregnant women’s hair increase as labor approaches, indicating higher stress.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

DHT in the human prostate is produced through multiple pathways, not just from testosterone.

Eating alfalfa sprouts every day can raise testosterone levels in middle-aged men, but broccoli sprouts don't have this effect.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Medicines that lower androgen levels and hair removal treatments help manage excessive hair and acne in women with PCOS.

A new method accurately measures nine specific hormones in human blood.

Child abuse is linked to higher BMI, but not because of hair cortisol or cortisone levels.

Androgen use may increase the risk of stroke, but more research is needed.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

Understanding genes and hormones is crucial for managing male puberty and sex development disorders.

Vitamin E affects liver metabolism, enhancing stress resistance, reducing blood clotting, and altering hormone processing.

Men with male pattern baldness don't necessarily have high levels of Dehydroepyandrosterone-sulfate, and there's no link between its levels and the severity of hair loss.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.