130 citations,
August 2015 in “Experimental Dermatology” Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.
82 citations,
May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Caffeine penetrates human skin in lab tests similarly to real-life conditions, but actual skin use is still essential for accurate results.
25 citations,
April 2006 in “British Journal of Dermatology” Finasteride lowers scalp and blood DHT levels, potentially treating male-pattern baldness.
November 2024 in “Journal of Investigative Dermatology” Minoxidil rejuvenates hair follicles and reduces aging signs in male pattern baldness.
1 citations,
April 2016 in “CRC Press eBooks” Skin aging reflects overall body aging and can indicate internal health conditions.
3 citations,
November 2018 in “PubMed” SMT effectively treats advanced baldness with high satisfaction.
130 citations,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).
April 2018 in “Journal of Investigative Dermatology” A new treatment using AGED to modulate PPAR-γ shows promise for treating scarring hair loss by protecting and repairing hair follicle cells.
20 citations,
April 2006 in “Dermatologic Clinics” Antiandrogen therapies are beneficial for treating skin and hair conditions related to androgen levels.
8 citations,
May 2021 in “Bioengineering & translational medicine” Hair growth environment recreated with challenges; stem cells make successful skin organoids.
January 2016 in “Human & Experimental Toxicology” A specific DNA sequence caused hair loss in male mice by activating immune cells and increasing a certain immune signal.
12 citations,
June 2016 in “Reviews in Endocrine and Metabolic Disorders” Some skin diseases and their treatments can negatively affect male fertility.
15 citations,
May 2020 in “BMC complementary medicine and therapies” Polygonum multiflorum extract helps hair grow longer and fights the effects of hormones that cause hair loss.
6 citations,
June 2011 in “British Journal of Dermatology” People with alopecia areata have higher levels of RBP4 protein and antibodies against it.
152 citations,
December 2007 in “Gender Medicine” Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.
5 citations,
June 2019 in “British Journal of Dermatology” Tofacitinib was more effective than apremilast in treating hair loss in a mouse model of alopecia areata.
24 citations,
April 2013 in “PLOS ONE” TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.
21 citations,
April 2012 in “European Journal of Pharmaceutics and Biopharmaceutics” The gel with special fat-loaded particles from rice bran could be an effective skin treatment for hair loss.
41 citations,
June 2006 in “Journal of Investigative Dermatology” Beard and scalp hair cells have different gene expressions, which may affect beard growth characteristics.
1 citations,
July 2024 in “Skin Research and Technology” Patients with androgenetic alopecia have thinner subcutaneous fat layers in their frontal scalp compared to healthy individuals.
29 citations,
April 2020 in “Journal of Tissue Engineering and Regenerative Medicine” The experiment showed that human skin grown in the lab started to form early hair structures when special cell clusters were added.
187 citations,
June 1999 in “Journal of The American Academy of Dermatology” Finasteride effectively treats frontal hair loss with few side effects.
October 2023 in “Asian journal of pharmaceutical and clinical research” Standardized data is essential for diagnosing scalp and hair conditions in males.
December 2022 in “Molecular Pharmaceutics” Latanoprost-loaded nanotransfersomes could help treat hair loss by promoting hair growth.
15 citations,
July 2017 in “PubMed” Injecting a mix of human skin and hair cells into mice can grow new hair.
19 citations,
August 2000 in “International Journal of Dermatology” Minoxidil and finasteride can slow or halt hair loss, but may have side effects.
41 citations,
March 1998 in “Archives of Dermatological Research” The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.
The conclusion is that closing scalp wounds is possible, but restoring hair without donor material is still a major challenge.
88 citations,
May 2005 in “Journal of Dermatological Science” Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.
14 citations,
January 2021 in “Stem cell research & therapy” Human skin cells with stem-like features can help create new hair follicles and sebaceous glands when combined with other cells.