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Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Hormonal therapy is a good option for women with severe acne, especially when there's a chance of hormone imbalance.

TURP is the best treatment for BPH, but some patients prefer medications like alpha-blockers and finasteride.

Hair loss may indicate higher heart risk and metabolic issues.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Testosterone and dihydrotestosterone have similar effects on body composition and metabolic health in men.

Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

People with alopecia are at higher risk for heart disease and have more heart-related risk factors.

Premature balding in some men may be linked to altered hormones, but it's not the male equivalent to polycystic ovary syndrome or metabolic syndrome.

In Japan, sex reassignment surgery for gender identity disorder faces challenges and needs better medical support and education.

Testosterone is crucial for development, growth, and various body functions in mammals.

Chicken feather gene mutation helps understand human hair disorders.

Hair loss in men can be slowed or reversed with treatments like minoxidil and finasteride, but it resumes if treatment stops. It may also indicate early heart disease and obesity.

High testosterone levels in 20% of the women studied may indicate PCOS, while 80% had low levels with potential health impacts.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Women with PCOS are more vulnerable to severe COVID-19 and related health issues.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.

Hormones and genes affect hair growth and male baldness.

Finasteride can cause sexual dysfunction, sperm changes, and affect bone density and metabolism.

The document concludes that the immune-inhibitory environment of the hair follicle may prevent melanoma development.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

The document explains how male reproductive hormones work and affect the body.

Testosterone therapy increases bone density in older men with low testosterone levels.

People with alopecia areata often have other health issues like skin diseases, metabolic syndrome, stomach infections, lupus, anemia, thyroid problems, mental health issues, vitamin D deficiency, and hearing and eye problems.