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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Transgender patients in critical care need better-trained medical staff and specific guidelines.

Women have a higher risk of blood clots from hormonal factors and need careful treatment, especially during pregnancy.

Non-binary transgender individuals need personalized hormonal treatments for better well-being and quality of life.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Sex hormones, especially estradiol, can change chicken feather shapes and colors.

Spironolactone is safe for treating female hair loss, but the safety of other drugs is uncertain.

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.

Hormone therapy is safe and effective for transgender adults, but requires regular monitoring and mental health support.

Early medical support for transgender youth is important for their health, with low regret for gender-affirming hormone use and a need for knowledgeable care providers.

Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.

Gender-affirming hormone therapy changes hair growth in transgender people, with feminizing therapy reducing hair and masculinizing therapy increasing it, but sometimes additional treatment is needed.

Healthcare providers need better understanding and cultural sensitivity to improve care for transgender patients with kidney failure needing transplants.

Testosterone therapy for postmenopausal women appears safe and may protect against heart disease, but requires constant monitoring and more research for long-term effects.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Testosterone undecanoate caused hair loss; finasteride improved it but caused stomach issues for one patient.

Certain drugs can worsen hair loss in people prone to androgenetic alopecia.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Testosterone replacement is recommended for men with low testosterone levels and symptoms of hypogonadism.

The document concludes that gender-affirming treatments are essential for transgender individuals and outlines safe hormone therapy practices.

Stress from being transgender is linked to higher blood pressure at night and more inflammation, which may affect heart health.

Testosterone therapy can modestly improve sexual function in menopausal women but should be used cautiously and is not recommended for routine measurement in sexual dysfunction or hirsutism.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Short-term testosterone therapy in women seems safe with few mild side effects, but long-term effects need more research.

Facial contouring is crucial for the satisfaction and well-being of Chinese transgender females.

The document concludes that personalized hormonal treatments are important for transgender individuals and more research is needed for non-binary treatments.

Pediatric endocrinologists should provide early fertility counseling and preservation options to young patients at risk of infertility.

Long-term high testosterone levels can improve bone density and reduce body fat but may increase the risk of prostate cancer and high blood pressure.

Transgender youth have more sleep disorders, but gender-affirming therapy may help reduce them.