64 citations
,
January 1985 in “Clinical endocrinology” In this study, treatment with the oral contraceptive containing 30 μg ethinyl oestradiol and 150 μg desogestrel significantly reduced androgen-dependent hair growth in hirsute women over one year.
7 citations
,
May 1983 in “Geburtshilfe und Frauenheilkunde” This study concluded that intramuscular administration of medium-dose cyproterone acetate with oral ethinylestradiol is highly effective in managing hirsutism, showing better response rates than high-dose oral treatment.
7 citations
,
March 2017 in “Experimental and Therapeutic Medicine” This study found that human hair follicle-derived mesenchymal stem cells effectively maintained human embryonic stem cells in an undifferentiated state, comparable to mouse embryonic fibroblasts under standard conditions.
May 2023 in “Animal Reproduction Update” This article reviews the use of hair cortisol concentration as a biomarker to assess long-term stress in both animals and humans, but it reports no new experimental results.
April 2024 in “Research Square (Research Square)” This study found that bioconjugating 16-methylheptadecanoic acid (16-MHA) to damaged hair can mimic the protective properties of 18-methyleicosanoic acid (18-MEA), restoring the hair's structural integrity and moisture homeostasis, even after washing.
3 citations
,
May 1990 in “Journal of Steroid Biochemistry” This study found that diagnosing non-classical 3 beta-hydroxysteroid dehydrogenase deficiency solely based on elevated serum or urinary 5-ene-steroids may not be reliable.
25 citations
,
March 2002 in “Scanning” This study highlights confocal microscopy as a promising, minimally invasive tool for assessing hair morphology and internal structures, making it valuable for cosmetic hair assessments.
September 2020 in “International journal of current pharmaceutical research” This study found that herbal creams containing tea tree oil significantly reduced hair growth in mice with hirsutism, while those containing reishi extract or both were less effective.
September 2009 in “Annales D Endocrinologie” This article reviews the clinical signs, diagnostic approaches, and treatment options for hyperandrogenism in women, focusing on hirsutism and specifies that cyproterone acetate is effective for severe cases, but reports no new clinical results.
January 1990 in “Medical Entomology and Zoology” This study developed a faster method for analyzing fatty acid ethyl esters in hair to help detect alcohol consumption levels, showing potential for applications in forensic and clinical settings.
The abstract does not report specific results but discusses cosmeceuticals in aesthetic dermatology, addressing myths, regulatory issues, and various compounds used for skin care.
15 citations
,
February 2015 in “Han-gug chugsan sigpum hag-hoeji/Korean journal for food science of animal resources” This study concludes that egg shell membrane hydrolysates, particularly Fraction I, may effectively mitigate UV-B radiation-induced wrinkles and promote skin collagen and hyaluronic acid production, suggesting potential use in functional cosmetics.
4 citations
,
February 2019 in “Journal of Cutaneous Pathology” This study suggests that the epigenetic marker 5-hmC may dynamically influence hair follicle bulge activation during anagen growth in mice, warranting further investigation into its role in stem cell regulation.
42 citations
,
December 1976 in “PubMed” This study found that the combination of cyproterone acetate and ethinyl estradiol improved hirsutism and acne in women, with SH 8.1041 showing significant results and both treatments being generally well-tolerated.
October 2025 in “Frontiers in Toxicology” This study found that a human relevant potency threshold for estrogen receptor alpha agonism may serve as a health-protective screening tool, and highlights inference performance as essential for scientific confidence frameworks.
11 citations
,
February 2008 in “British journal of nursing” This article reviews idiopathic hirsutism, focusing on its definition, diagnosis, causes, and treatment options, without presenting new clinical findings.
January 2000 in “Zhongguo yixue wulixue zazhi” This study observed that human hair keratin showed distinct morphological features depending on the dissolution speed, which could have potential applications in clinical settings for developing self-tendons.
29 citations
,
February 2017 in “International Journal of Women's Dermatology” This article provides an endocrine perspective on evaluating and managing hirsutism but reports no new research findings.
12 citations
,
August 2022 in “Ecotoxicology and Environmental Safety” This study developed and validated a method using hair samples to simultaneously detect bisphenols and parabens, enabling the quantification of these endocrine disruptors in a hospital population’s hair.
March 2025 in “Plastic & Reconstructive Surgery Global Open” This study reported that participants applying topical human platelet exosome extract serum experienced significant improvements in hair volume, density, scalp coverage, and overall hair health compared to a placebo, and no adverse effects were observed.
May 2026 in “Animal Bioscience” This study found that m6A-circHECA enhances the differentiation of stem cells into hair follicle lineages in cashmere goats by sequestering miR-449a-5p, boosting LEF1 gene expression, and activating the Wnt/β-catenin pathway.
13 citations
,
January 2012 in “Dermatologic surgery” This study found that the cross-section trichometer is a promising tool for measuring hair mass index with high reproducibility, suggesting potential clinical and research applications.
1 citations
,
December 1970 in “European journal of endocrinology” This study reports experience treating 140 women with hirsutism and other virilism signs using cyproterone acetate and ethinyl estradiol, focusing on those treated for over five months.
September 1978 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” This review discusses the antimicrobial and protective effects of hesperidin and hesperetin against various toxicities, with potential mechanisms explored, but it reports no new research findings.
17 citations
,
February 1989 in “Fertility and sterility” In this study, cimetidine at a daily dose of 1.5 gm for 3 months did not significantly affect hair growth in women with moderate to severe hirsutism.
195 citations
,
May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology” This review discusses the diagnosis and treatment of hirsutism, emphasizing that a systematic evaluation can determine its cause, while combination therapy effectively manages the condition for most patients.
12 citations
,
August 2017 in “Pharmaceutical medicine” This study found that physician knowledge of thromboembolism risk associated with cyproterone acetate/ethinylestradiol was generally high, although it varied for complex or less common topics.
30 citations
,
January 2009 in “Nuclear Receptor Signaling” This study identified the Hairless (Hr) gene-encoded protein as a corepressor that plays a crucial role in maintaining skin and hair by regulating epithelial stem cell differentiation and gene expression via chromatin remodeling, which may impact both development and disease.
9 citations
,
November 2012 in “Biomolecules & therapeutics” This study found that diphlorethohydroxycarmalol significantly increased prostaglandin $E_2$ synthesis in HaCaT human keratinocytes by upregulating COX-1 and COX-2 expression, suggesting potential benefits from elevated $PGE_2$ production.
6 citations
,
April 2009 in “Obstetrician & gynaecologist/The obstetrician & gynaecologist” This article reviews the assessment, causes, and management approaches for hirsutism in women, emphasizing ethical considerations concerning unapproved drug use and contraceptive responsibility but reports no new clinical findings.