January 2000 in “Zhongguo yixue wulixue zazhi” This study observed that human hair keratin showed distinct morphological features depending on the dissolution speed, which could have potential applications in clinical settings for developing self-tendons.
December 2000 in “日本組織細胞化学会総会プログラムおよび抄録集”
11 citations
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October 2015 in “Clinical and Experimental Dermatology” This study found that an extract from the root of Sophora flavescens Aiton significantly improved hair growth in patients with androgenetic alopecia over 6 months.
This study demonstrated that cryogelation of human hair keratin allows the development of 3D scaffolds with tunable properties, supporting cell adhesion and proliferation for potential biomedical applications.
May 2005 in “Zhonghua chuangshang guke zazhi” This study found that human hair keratin bridges effectively induced nerve regeneration and demonstrated good biocompatibility and controlled degradation when used in rats with peripheral nerve defects.
This study suggests that human hair keratin-based gradient hydrogels incorporating silver ions may serve as promising dermal templates for wound healing, demonstrating favorable mechanical properties, cell interaction, and antibacterial activity.
5 citations
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October 2002 in “PubMed” In this study, the degradation of HHK scaffold particles was linked to the activation and proliferation of satellite cells, which may contribute to new muscle fiber formation.
January 2003 in “Zhongguo linchuang jiepouxue zazhi” In this rat study, HHK implantation after spinal cord injury did not significantly improve locomotion but may have integrated into the spinal tissue, potentially aiding recovery and reconstruction.
1 citations
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July 2008 in “PubMed” This article reviews the protective and regenerative mechanisms of nerve fibers and Schwann cells after injury but reports no new findings.
November 2010 in “PubMed” Human hair keratin can help repair fat tissue.
January 2005 in “Zhonghua chuangshang guke zazhi” This study found that human hair keratin can effectively induce peripheral nerve regeneration in rats, showing good biocompatibility and a controllable degradation rate when used as a scaffold material.
January 2002 in “中国人民解放军军医大学学报(英文版)” This study found that human hair keratin scaffold material implanted in damaged rabbit muscle tissue degrades via the ubiquitin system and is further processed by macrophagocytes and lysosomes.
January 2001 in “Zhongguo linchuang jiepouxue zazhi” This study found that transplanted human hair keratin may help reduce damage and promote function recovery in spinal cord injuries in rats.
January 2002 in “Academic Journal of Kunming Medical College” In this study, human-hair artificial tendon material showed good biocompatibility and variable degradation rates in rabbits, depending on treatment time, with minimal inflammatory reactions observed.
January 1999 in “Chinses Journal of Hand Surgery” This study found that human hair keratin artificial tendons have low antigenity and may serve as an effective substitute for tendon repair in the upper extremities.
January 2003 in “Jiepouxue zazhi” This study found that human hair keratin can serve as a matrix for skin structure restoration, as observed in rats where the graft was replaced by newly formed collagenous fibers over six weeks.
141 citations
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August 2017 in “Developmental Dynamics” This review discusses the cellular and molecular changes involved in cutaneous wound re-epithelialization and EMT, highlighting their similarities and differences, but reports no new clinical results.
32 citations
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February 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports the cloning and sequencing of two type II hair-specific keratin genes, ghHb1 and ghHb6, located on chromosome 12q13, which are expressed during hair growth.
1 citations
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January 2018 in “Recent clinical techniques, results, and research in wounds” This review discusses the similarities between wound healing and embryonic development, focusing on signaling pathways and their potential for developing new wound healing strategies, and reports no new clinical results.
This dissertation reported that the loss of Ovol2 impairs hair follicle regeneration and wound repair in mice, highlighting its role in regulating directional migration of epithelial cells.
August 2022 in “Research Square (Research Square)” This study found that implanting HAP stem cells in a mouse model accelerated wound closure and reduced scar formation, suggesting potential for scar-free wound healing.
11 citations
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October 2002 in “Genetics” This study mapped a spontaneous mouse hair mutation, "hague," to keratin genes on chromosome 15 but found no gene mutations in hague mice.
February 1985 in “PubMed” 13 citations
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August 1985 in “The Journal of Dermatology” This study identified a monoclonal antibody, HKN-2, that recognizes specific cells in human skin and may indicate a common antigenic determinant between hair and other skin epithelial tissues.
86 citations
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May 2002 in “Journal of Investigative Dermatology” This study characterized a new human keratin, hK6irs1, specifically found in the inner root sheath of hair follicles, which suggests its role in the structural integrity and guidance of growing hair shafts.
139 citations
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December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a new type II cytokeratin, named K6hf, exclusively expressed in the companion layer of the human hair follicle, distinguishing it from other keratins and suggesting a unique biochemical role.
January 2002 in “Proceedings of The Japanese Society of Animal Models for Human Diseases” In this study, researchers observed distinct morphological differences in hair follicles of mutant mouse genotypes, influenced by the expression levels of keratin2-6g, which is essential for proper hair follicle development.
126 citations
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October 1998 in “Experimental Dermatology” This review provides an overview of the hairless gene in mice and humans, discussing its structure, expression, and implications for understanding skin physiology and human disorders related to gene disruption, but it reports no new empirical findings.
September 2016 in “Journal of Dermatological Science” This study reports a case of GGCX syndrome in a 55-year-old Japanese male, characterized by PXE-like symptoms and coagulation deficiency, with an unreported phenotype of possible spinocerebellar degeneration.
4 citations
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January 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that the KLHL24-ΔN28 protein variant disrupts hair follicle stem cells in a mouse model, leading to premature hair loss by degrading keratin 15.