Histopathological Analysis on Keratin2-6g Expression in Hair Mutant Mouse Hague

    January 2002 in “ Proceedings of The Japanese Society of Animal Models for Human Diseases ”
    Atsushi Yoshiki, Jun Inoue, Yoshitaka YATSUDA, Moriaki Kusakabe
    TLDR Keratin2-6g is crucial for hair follicle development, with mutations causing cell degeneration and vacuolation.
    The study investigated the histopathological characteristics of hair follicles in a spontaneous mouse hair mutation called Hague, found in C3H/HeN mice, focusing on the expression of keratin2-6g. The research compared hair follicle morphology across different genotypes: wild type, semidominant heterozygotes, semidominant homozygotes, and recessive homozygotes. It was found that semidominant homozygotes (Hag/Hag) exhibited significant degeneration and vacuolation in the inner root sheath (IRS) cells, while semidominant heterozygotes (Hag/+) showed less vacuolation. Recessive homozygotes (hag/hag) did not show vacuolation but had larger tricohyaline granules. The expression of keratin2-6g was minimal, and the protein was undetectable in mutants, suggesting its essential role in hair follicle development and differing effects of Hag and hag alleles on IRS cells.
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