Degradation of Human Hair Keratin Scaffold Material Used to Repair Injured Skeletal Muscles of Rabbits

    January 2002 in “ 中国人民解放军军医大学学报(英文版) ”
    Wenyu Fu
    TLDR Human hair keratin scaffold material degrades in muscles mainly through the ubiquitin system with lysosome help.
    The study investigated the degradation mechanism of human hair keratin (HHK) scaffold material in injured skeletal muscles of six New Zealand rabbits. The HHK material, with varying degradation speeds, was implanted in the rabbits and observed over 1, 3, and 6 weeks. Results showed that the HHK material degraded into particles, which were phagocytosed by macrophagocytes and multinucleate giant cells. The degradation process involved the ubiquitin system, with enzymatic histochemistry indicating positive results for these cells at the first week. By the sixth week, further degradation of the HHK material was observed. The study concluded that the HHK scaffold material was primarily degraded through the ubiquitin system, with lysosomes aiding in the breakdown of the resultant particles.
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