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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

New treatments for male hypogonadism are effective and should be personalized.

Non-biologic immunosuppressive drugs are crucial for treating autoimmune and chronic inflammatory skin diseases.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.

Early treatment and weight management are important for teenagers with PCOS to reduce symptoms and long-term health risks.

The circadian clock plays a key role in hair growth and its disruption can affect hair regeneration.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Eating pacu-manteiga fish can cause Haff disease, leading to severe muscle damage.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

The document concludes that personalized hormonal treatments are important for transgender individuals and more research is needed for non-binary treatments.

Biologics for severe asthma have known side effects, but some new risks need more study.

Melatonin may help manage PCOS by improving insulin sensitivity, hormone balance, and mood.

Melatonin, a hormone, can help protect skin from aging by reducing stress, inflammation, and damage, and may also help treat hair loss in women.

Scientists found a new, less invasive way to study body clocks using hair cells, which shows shift workers' body clocks don't match their lifestyles.

Acne is a common skin condition that can be influenced by diet, lifestyle, and hormones, and requires a treatment approach that includes psychological considerations.

PCOS in India is linked to broader sociocultural and environmental changes, not just diet and exercise.

Transgender youth have more sleep disorders, but gender-affirming therapy may help reduce them.

International medical graduates outperformed U.S. graduates on an internal medicine exam.

International medical graduates scored higher than U.S. graduates on a medical exam.

International medical graduates outperformed U.S. graduates on an internal medicine exam.

In 1995, international medical graduates did better than U.S. graduates on a medical exam.

Itraconazole may cause low platelet and white blood cell counts.

Healthy lifestyle changes can significantly improve skin health as you age.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

The model and estimator can predict drug exposure in kidney transplant patients well.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Autonomic dysfunction is common in hypertensives but may not cause diastolic dysfunction in resistant hypertension.

Androgen receptors in the mouse brain may explain cognitive and mood changes in prostate cancer treatment.