Haff Disease Associated With The Ingestion Of The Freshwater Fish Mylossoma Duriventre (Pacu-Manteiga)

    January 2013 in “ Revista Brasileira De Terapia Intensiva ”
    Oswaldo Tolesani Júnior, Christian Nejm Roderjan, Edgard do Carmo Neto, Micheli Mikaeli Ponte, Mariana Cristina Pelli Seabra, Marcos Freitas Knibel
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    TLDR Eating pacu-manteiga fish can cause Haff disease, leading to severe muscle damage.
    The document describes a case of Haff disease in a 48-year-old male who developed rhabdomyolysis after consuming the freshwater fish Mylossoma duriventre (pacu-manteiga). The patient experienced severe abdominal pain, vomiting, muscle pain, weakness, and dark urine about 2 hours post-ingestion, without fever or neurological issues. Laboratory tests showed extremely high levels of creatine phosphokinase (CPK) and myoglobin, confirming rhabdomyolysis. He was treated with intravenous hydration and bicarbonate, and discharged after 8 days with normalized muscle injury markers. This case, which occurred three years after an outbreak in Manaus, Brazilian Amazon, highlights the need to consider Haff disease in similar clinical presentations and calls for more research to identify the causative toxin in fish.
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