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Higher DHT levels are linked to worse heart changes in severe aortic valve stenosis patients.

Testosterone's muscle-building effects do not require its conversion to DHT.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

The chapter explains the causes of excessive hair growth and masculinization in women and how to measure hormone levels related to these conditions.

Hormones are crucial for regulating body functions and imbalances can lead to health issues.

Pharmacists should interpret lab data and perform physical exams to improve patient care.

Skin, hair, and nail changes can help detect eating disorders early.

Bezafibrate treatment improved skin and spleen health in aging mice but didn't extend lifespan.

Mice with autoimmune hair loss showed signs of heart problems.

Gene therapy in mice increased lifespan and improved health without causing cancer.

Myotonic Dystrophy may age cells faster, and drugs that target aging could be potential treatments.

Progeroid mouse models show signs of early aging similar to humans, helping us understand aging better.

Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.

Men with male pattern baldness had higher body fat and obesity-related measurements but similar heart fat and artery thickness compared to healthy men.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

High androgen levels can cause excessive hair growth and may indicate serious health issues, including heart disease and fertility problems.

Enobosarm significantly increased muscle mass and improved physical function in elderly men and postmenopausal women without serious side effects.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.

Minoxidil can cause heart muscle damage in dogs.

When treating older patients with both heart valve disease and heart muscle disease, doctors should create personalized treatment plans that address both conditions.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

Testosterone replacement therapy improves libido, mood, muscle strength, and bone density in men with Testosterone Deficiency Syndrome.

Rehabilitation therapy helped a severe COVID-19 patient regain muscle mass and return to normal life.

Hyperandrogenism increases heart disease risk in premenopausal women, but this risk is linked to obesity in postmenopausal women.