7 citations
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October 2011 in “BMC Cancer” This study found no evidence that HDGF expression transforms melanocytes into tumors in a mouse model, although it may play a role in cell differentiation and tumor progression.
This study utilized a pigmented human epidermal equivalent model to incorporate melanocytes into the epidermis and found enhanced differentiation potential compared to conventional in vitro systems, reflecting in vivo cellular trajectories and highlighting melanocyte-to-keratinocyte communication pathways.
This study identified 193 plasma proteins associated with prostate cancer risk, validating 20 high-risk proteins including KLK3, and pinpointed potential drug targets like HSPB1, RRM2B, and PSCA through genetic analysis, offering new insights for biomarkers and treatments.
March 2024 in “Cytologia” In this study, researchers observed that melatonin-mediated LncRNA MTC in Liaoning cashmere goat skin fibroblasts enhances cell proliferation by interacting with the GSTM1 protein, affecting its complex formation with ASK1 and thereby inhibiting apoptosis, which may be relevant for improving cashmere growth.
This study examined the molecular communication in psoriasis cells, highlighting unique immune cell interactions and identifying new features of the hair follicle cell-psoriasis axis. It suggests the potential for targeted therapies at the single-cell level to improve psoriasis treatment.
January 2021 in “Journal of cosmetology & trichology” This study suggests that L-(+)-Tartaric Acid may support hair growth by up-regulating certain genes in human Dermal Papilla cells, making it a potentially useful additive in minoxidil formulations.
January 2012 in “RWTH Publications (RWTH Aachen)” This study found that patient-derived HGF significantly accelerates wound healing in diabetic mice, particularly improving skin structure and flexibility, and rHGF plays a key role in boosting hair growth.
77 citations
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February 2001 in “Journal of Dermatological Science” HGF activator helps convert HGF to its active form, promoting hair growth.
66 citations
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April 1995 in “The journal of cell biology/The Journal of cell biology” In this study, researchers reported that a keratinocyte growth factor-Ig fusion protein could specifically detect and localize KGFRs in epithelial tissues, suggesting a method for histochemical detection of growth factor receptors.
109 citations
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April 1998 in “Journal of Investigative Dermatology” This study found that recombinant human HGF/SF injections altered hair follicle growth cycles and mildly promoted hair elongation in mice, depending on their hair cycle stage.
33 citations
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December 1999 in “Journal of Investigative Dermatology Symposium Proceedings” 20 citations
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December 2019 in “International Journal of Molecular Sciences” This study found that preconditioning adipose-derived stem cells with HB-EGF enhanced their ability to promote hair growth in vivo by increasing their motility, paracrine effects, and survival.
12 citations
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February 2023 in “Stem Cell Research & Therapy” This study found that injecting hepatocyte growth factor-enhanced hair follicle stem cells into a rat model of ischemic stroke improved recovery by reducing inflammation, protecting the blood-brain barrier, and promoting angiogenesis.
April 2016 in “Journal of Investigative Dermatology” This study suggests that hepatocyte growth factor (HGF) may play a role in hair follicle neogenesis and that an HGF mimetic could enhance skin substitute development.
2 citations
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January 2009 in “Human cell culture” 4 citations
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July 2023 in “Frontiers in Microbiology” HGF combined with ADA is highly accurate for diagnosing tuberculous pleural effusion, especially in younger females.
2 citations
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May 2017 in “International journal of pharmacy and pharmaceutical sciences/International Journal of Pharmacy and Pharmaceutical Sciences” This review discusses genetic mutations associated with Hutchinson-Gilford progeria syndrome and reports no clinical results; the authors emphasize the importance of cardiovascular monitoring in management.
26 citations
,
August 2009 in “Journal of Pediatric Gastroenterology and Nutrition” This study reports that gastrointestinal problems, such as intractable diarrhea and enterocolitis, can dominate the clinical course of patients with Hoyeraal-Hreidarsson syndrome and may occur before hematological and immunological symptoms.
4 citations
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June 1998 in “The Journal of Clinical Endocrinology & Metabolism” This study found that keratinocyte growth factor is a potent mitogen in human hyperplastic prostate cells, suggesting it plays an important role in prostate growth by acting in a paracrine manner.
7 citations
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July 2019 in “International Journal of Molecular Sciences” This study found that PGA-4HGF nanoparticles enhanced hair growth in mice more effectively than 4HGF alone by increasing anagen phase duration and dermal papilla cell proliferation.
1 citations
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January 2023 in “Journal of Clinical Medicine” This study reported that Tomorrowlabs HIF strengthening factor [HSF] hair restoration technology significantly improved hair thickness, density, shine, and elasticity, while reducing hair loss by an average of 66.8% and enhancing hair growth by up to 32.5% in subjects with androgenic alopecia over nine months.
March 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers developed a new method called Enriched-GF, which enhances growth factor recovery from platelet concentrates through a combination of glass bead activation, freeze-thaw cycling, and calcium stimulation, outperforming conventional methods by providing higher and more consistent yields for regenerative medicine applications.
January 2010 in “프로그램북(구 초록집)” Fgf9 helps create new hair follicles after injury through skin T cells.
24 citations
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July 1994 in “Molecular Endocrinology” Researchers found an RNA transcript that might help control a growth factor linked to tumor development.
58 citations
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April 2012 in “Journal of the American Academy of Dermatology” Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.
March 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that human dWAT regulates hair growth and pigmentation through HGF secretion, highlighting potential novel targets for treating hair growth and pigmentation disorders.
1 citations
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September 2016 in “Journal of Dermatological Science” This study found that FGF18 signaling helps protect hair follicles from radiation damage by maintaining the resting phase and supporting stem cell survival, potentially reducing radiation-induced hair loss.
14 citations
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November 2013 in “PloS one” This study found that transgenic mice overexpressing HGF/SF are more susceptible to UVA-induced melanoma, with melanin in the papillary dermis interacting with UVA to induce melanoma.
1 citations
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February 2021 in “Scholars international journal of anatomy and physiology” In a laboratory setting, this study found that overexpression of the FGF5 short form in cultured keratinocytes increased hepatic growth factor gene expression, suggesting a potential role in hair growth.
November 2022 in “Journal of Investigative Dermatology” This study found that human scalp hair follicles produce neurohormones and responded to GHRH stimulation by prolonging hair growth, suggesting a functional peripheral HPS neuroendocrine signaling axis in the skin.