Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation

March 2021 in “ Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ”

Jiro Kishimoto, Yumiko Ishimatsu‐Tsuji

dermal white adipose tissue dWAT hair follicles HFs HGF c-Met signaling perifollicular region

Studysummary This study found that human dWAT regulates hair growth and pigmentation through HGF secretion, highlighting potential novel targets for treating hair growth and pigmentation disorders.

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The study by Nicu C et al. demonstrated that dermal white adipose tissue (dWAT) surrounding hair follicles (HFs) plays a crucial role in regulating human hair growth and pigmentation through HGF/c-Met signaling. This finding suggested that targeting HGF/c-Met signaling in the perifollicular region could offer a novel therapeutic approach for treating disorders related to human hair growth and pigmentation.

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