Causal Associations Between Plasma Proteins and Prostate Cancer: A Proteome-Wide Mendelian Randomization

    September 2024
    Lin Chen, Zhuona Rong, Yanlun Gu … Xiaocong Pang
    Studysummary This study identified 193 plasma proteins associated with prostate cancer risk, validating 20 high-risk proteins including KLK3, and pinpointed potential drug targets like HSPB1, RRM2B, and PSCA through genetic analysis, offering new insights for biomarkers and treatments.
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    Research cited in this study 3

    1. Assessment of the Usefulness of Dihydrotestosterone in the Diagnostics of Patients with Androgenetic Alopecia Postepy Dermatologii I Alergologii · 2014
    2. 5α-Reductase Type 2 Gene Variant Associations with Prostate Cancer Risk, Circulating Hormone Levels, and Androgenetic Alopecia International Journal of Cancer · 2006
    3. The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia Cancer Epidemiology, Biomarkers & Prevention · 2005