Causal Associations Between Plasma Proteins and Prostate Cancer: A Proteome-Wide Mendelian Randomization

This study investigated the causal relationships between plasma proteins and prostate cancer (PCa) to identify potential biomarkers and therapeutic targets. A meta-analysis of two genome-wide association studies (GWASs) involving 94,397 individuals with PCa and 192,372 controls was conducted. The study identified five susceptibility loci (JAZF1, PDILM5, WDPCP, EEFSEC, and TNS3) and 193 plasma proteins associated with PCa risk, with 20 high-risk proteins validated in two cohorts. Functional annotation revealed enrichment in immune and inflammatory responses. Potential drug targets, such as HSPB1, RRM2B, and PSCA, were also identified. These findings provide insights into PCa etiology and contribute to developing novel biomarkers for early detection and therapeutic interventions.