Hepatocyte Growth Factor Combined With Adenosine Deaminase As Biomarker For Diagnosis Of Tuberculous Pleural Effusion
July 2023
in “
Frontiers in Microbiology
”
TLDR HGF combined with ADA is highly accurate for diagnosing tuberculous pleural effusion, especially in younger females.
The study evaluated the diagnostic efficacy of combining hepatocyte growth factor (HGF) with adenosine deaminase (ADA) for diagnosing tuberculous pleural effusion (TPE) in 97 TPE and 116 non-TPE subjects. It found that HGF levels were significantly higher in TPE patients. The combination of HGF and ADA showed high diagnostic accuracy, especially in female TPE patients aged ≤65 years, with an area under the curve (AUC) of 0.998, sensitivity of 100%, and specificity of 96.667%. This indicates that HGF plus ADA could be an excellent biomarker for diagnosing TPE, particularly in younger females.
