This study found that in mice with alopecia areata, a single subcutaneous injection of botulinum neurotoxin serotype A significantly reduced hair loss and stimulated hair follicle regeneration.
September 2023 in “JPRAS Open” This review discusses botulinum toxin A as a treatment for various types of hair loss and reports no clinical results; the authors emphasize the need for comprehensive evaluations and further research.
April 2024 in “Skin research and technology” This study suggests that while subcutaneous Botulinum Toxin Type A may offer short-term symptom improvement for female pattern hair loss, its effectiveness does not extend beyond three months.
June 2026 in “Dermatology and Therapy” In this retrospective analysis, patients with trichodynia who were unresponsive to standard treatments showed significant symptom improvement after receiving intradermal botulinum toxin type A, with nearly all patients benefiting, particularly those with scarring alopecia.
3 citations
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January 2022 in “Neurotoxicity Research” This study found that botulinum toxin type A injections in stressed mice appeared to normalize hair follicle regeneration cycles and reduced stress-related hair loss indicators.
This paper reviews the effectiveness and side effects of various treatments for androgenetic alopecia, telogen effluvium, and alopecia areata, emphasizing the importance of discussing each option's costs, benefits, and risks with patients.
August 2023 in “Journal of Dermatological Treatment” This systematic review concluded that mesotherapy shows potential for improving hair growth outcomes, yet lacks standardized regimens and requires further large-scale trials to establish its efficacy and safe use.
This extended abstract discusses various treatments for alopecia, including low-level light therapy, which has shown promise but requires further research to establish effectiveness, especially in combination with other therapies.
1 citations
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September 2021 in “Skin appendage disorders” This systematic review of five studies found that intradermal and intramuscular botulinum toxin injections showed promising hair growth outcomes for men with androgenic alopecia, but emphasizes caution due to a lack of control groups and small sample sizes.
This study found that subcutaneous administration of Botulinum toxin type A significantly reduced histamine-induced itch intensity and neurogenic inflammation in human skin compared to saline.
53 citations
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January 2017 in “Skin appendage disorders” This review discusses botulinum toxin's experimental off-label uses in dermatology, highlighting promising results but emphasizing the need for more clinical trials to confirm efficacy and safety.
Botulinum toxin injections can reduce hair loss and stimulate new hair growth in some men with male pattern baldness.
Botulinum toxin-A may increase hair growth and reduce hair loss in men with baldness, and injecting near blood vessels can improve pain relief and last longer.
July 2005 in “CME: Your SA Journal of CPD” This review discusses the use of botulinum toxin as a treatment for chronic headache, highlighting its safety and acceptance among patients, but reports no new clinical results; the authors stress the need for comparative studies with standard treatments.
15 citations
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May 2013 in “Ophthalmic Plastic and Reconstructive Surgery” In this case study, repetitive botulinum type A toxin injections led to almost complete resolution of severe chronic pain in a patient with Parry-Romberg syndrome.
3 citations
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April 2022 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses evidence-based complementary strategies for enhancing hair regrowth after post-COVID-19 telogen effluvium and reports no new clinical results.
March 2023 in “JAAD case reports” In this study, researchers reported that conventional treatments for folliculitis decalvans, which include steroids and antibiotics, are often ineffective, with many patients experiencing frequent recurrences of this scarring scalp disorder.
March 2022 in “IntechOpen eBooks” This chapter discusses the potential therapeutic applications of Botulinum toxin for various non-cosmetic skin conditions, such as acne, rosacea, and hyperhidrosis, highlighting case reports and some randomized controlled trials that indicate promise in alleviating discomfort, inflammation, and excessive sweating.
April 2016 in “Journal of Clinical Research in Dermatology” This report describes a case of sclero-atrophy localized to the frontal scalp following an injection of botulinum toxin type A, which has not been previously documented in the literature.
This study introduced a customizable ELISA for detecting antibodies against botulinum neurotoxin that matches or surpasses other tests in sensitivity and allows for more efficient and animal-friendly testing when combined with the hemidiaphragm assay.
Botulinum toxin-A injections in the scalp can reduce hair loss and promote new hair growth in men with certain types of baldness.
December 2021 in “Intisari Sains Medis” This case report describes a 29-year-old woman with Female Pattern Hair Loss whose hair thinning reduced one month after botulinum toxin treatment.
June 2025 in “Fayoum University Medical Journal/Fayoum University Medical Journal ” This study found that both intralesional minoxidil 8% and botulinum toxin type A were equally effective in treating female pattern hair loss, with no significant difference in results between the two treatments.
February 2025 in “Journal of Cosmetic Dermatology” This case report describes a 34-year-old Asian female who experienced prolonged localized facial blanching following botulinum toxin type A injection, marking the first such documented case in this population.
February 2005 in “Journal of The American Academy of Dermatology” Doctors should recognize various nail disorders, new allergens, and metabolic syndrome in patients, and use botulinum toxin carefully in aesthetic procedures.
September 2024 in “Journal of the American Academy of Dermatology” Botulinum toxin is not effective for treating male hair loss.
219 citations
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January 2005 in “Plastic & Reconstructive Surgery” This study found that surgical deactivation of migraine headache trigger sites can significantly reduce migraine symptoms, with 92% of patients reporting at least a 50% reduction in migraine frequency, duration, or intensity.
191 citations
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December 2013 in “Plastic & Reconstructive Surgery” This study found that surgical deactivation of migraine trigger sites significantly reduced or eliminated migraine symptoms in most treated patients, compared to controls, and also decreased migraine-associated costs and workdays lost.
34 citations
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July 2020 in “Dermatologic Therapy” This study observed increased online searches for "acne," "eczema," and "hair loss" but decreased interest in "botox," "skin cancer," and some other terms during the COVID-19 pandemic in Turkey and Italy.
24 citations
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February 2004 in “Plastic & Reconstructive Surgery” This book provides a comprehensive guide to cosmetic dermatology, emphasizing practical applications of skin care in cosmetic and surgical practices, but it reports no new clinical findings.