25 citations,
September 2014 in “Biological Research” Arctiin helps protect hair cells from damage and death caused by oxidative stress.
October 2005 in “Nature reviews. Molecular cell biology (Print)” Hairless protein is key for hair growth, cell differences cause gene expression variation, and the N-end rule pathway senses nitric oxide for protein breakdown.
185 citations,
December 2011 in “Molecular and cellular endocrinology” Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.
158 citations,
August 2011 in “Reviews in endocrine and metabolic disorders” Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.
67 citations,
August 2007 in “American Journal of Pathology” Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.
56 citations,
August 2005 in “Journal of Investigative Dermatology Symposium Proceedings” Different women's hair and skin glands respond to hormones in varied ways, which can cause unwanted hair growth even with normal hormone levels, and more research is needed to treat this effectively.
39 citations,
January 2013 in “Journal of Investigative Dermatology” Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.
24 citations,
March 2018 in “Pigment Cell & Melanoma Research” The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.
20 citations,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” Minoxidil and finasteride can help with hair loss, but more research is needed to improve treatments for certain types of hair loss.
16 citations,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” New treatments and early diagnosis methods for permanent hair loss due to scar tissue are important for managing its psychological effects.
10 citations,
May 2012 in “Cell Adhesion & Migration” ILK and ELMO2 help cells move and stick together, important for wound healing and hair growth.
1 citations,
January 2013 in “Journal of Investigative Dermatology” The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.
October 2017 in “Journal of Investigative Dermatology” HIF-1A may aid hair growth, Backhousia citriodora improves skin, autologous cells stabilize hair loss, infrared thermography assesses alopecia, and a new treatment preserves hair.
January 2012 in “Elsevier eBooks” New treatments for skin and hair repair show promise, but further improvements are needed.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
421 citations,
April 2012 in “The New England Journal of Medicine” Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.
139 citations,
February 2014 in “Journal of Advanced Research” Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.
57 citations,
March 2019 in “Immunity” The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.
53 citations,
June 2017 in “Skin appendage disorders” PRP treatment helps hair growth in most cases, but more research needed.
36 citations,
April 2013 in “Cell and Tissue Research” Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.
35 citations,
April 2011 in “Journal of Biological Chemistry” sPLA2-X is crucial for normal hair growth and follicle health.
30 citations,
November 2018 in “EMBO Reports” The Ovol2-Zeb1 circuit is crucial for skin healing and hair growth by guiding cell movement and growth.
25 citations,
May 2013 in “Journal of mammary gland biology and neoplasia” Hedgehog signaling is crucial for mammary gland development over hair follicles.
24 citations,
June 2019 in “Journal of Cosmetic Dermatology” Scalp microneedling may improve hair density and thickness for various alopecia types.
24 citations,
July 2018 in “Stem cells” Runx1 controls fat-related genes important for normal and cancer cell growth, affecting skin and hair cell behavior.
23 citations,
June 2019 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.
17 citations,
June 2017 in “British Journal of Dermatology” The article concludes that hair loss is a common side effect of drugs treating skin cancer by blocking the hedgehog pathway, but treatment should continue, and more selective drugs might prevent this side effect.
14 citations,
October 2018 in “PloS one” Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.
13 citations,
April 1994 in “Journal of Investigative Dermatology” Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
8 citations,
June 2021 in “Lasers in Medical Science” LLLT helps treat hair loss by increasing blood flow, reducing inflammation, and stimulating growth factors.