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We need better ways to test and understand SARMs to make safer and more effective treatments.

Acne is caused by increased sebum, abnormal skin shedding, bacteria, and inflammation, not dirt; treatments vary from creams to antibiotics or isotretinoin, with severe cases needing a dermatologist's care.

Mutations in the androgen receptor gene cause different levels of androgen insensitivity, making it hard to create simple tests for the condition.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Oestrogens are key for bone growth during puberty in both boys and girls.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Estrogens are key for bone growth spurts in both boys and girls and affect growth into adulthood.

The document concludes that managing PCOS involves treating symptoms and reducing long-term metabolic risks, with lifestyle changes being important.

Testosterone is crucial for development, growth, and various body functions in mammals.

Fermented soy protein may help prevent bone loss by affecting bone cell activity.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

A woman with childhood growth hormone deficiency had multiple hormone deficiencies and developed serious lung and kidney problems later in life.

Testosterone replacement therapy helps manage deficiency and has various methods, but requires careful monitoring to avoid side effects.

Certain ESR1 gene variations may affect hormone levels and fat distribution in women with high male hormone levels.

Mouse genital development depends on male or female hormones for specific features.

Hormone therapy improves mental well-being in transgender individuals but requires ongoing health monitoring.

Androgen treatment with dihydrotestosterone may help maintain height in patients with 5-α-reductase type 2 deficiency, especially before puberty.

More research is needed to understand how testosterone is maintained in adult males.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Ephrins slow down skin and hair follicle cell growth.

Ionizing radiation damages human hair follicles by stopping cell growth, causing cell death, disrupting color, and increasing stress and damage markers.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.