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The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

The enzyme Rand protease works well for leather dehairing and its stability is important, with Leu75 playing a key role.

Some existing drugs and natural products might work against COVID-19 by targeting the virus's main protease.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Some common medications can harm male fertility, but many effects can be reversed.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.

Good feather growth in poultry needs the right balance of proteins, amino acids, minerals, and vitamins.

Inducing ferroptosis in hepatic stellate cells is crucial for treating liver fibrosis.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

L-PGDS has specific binding sites for its functions and could help in drug delivery system design.

Nanotechnology shows promise for better drug delivery and cancer treatment.

Transglutaminase activity is important for skin and is found in both mammals and birds.

Autophagy prevents early aging and maintains lipid and pheromone balance in mouse glands.

Dr. Marina Kovalevsky and her daughter were hospitalized for suspected politically motivated thallium poisoning in Moscow.

Small proline-rich proteins and trichohyalin help make epithelial tissues tougher and more flexible.

Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.

Thallium is highly toxic, causing severe health issues, and Prussian blue is the best antidote.

Keratin proteins are essential for keeping the cells in the human colon healthy and stable.

Melanin may help melanoma cells grow by aiding their metabolism.

Understanding keratinization is crucial for treating skin conditions like ichthyoses and psoriasis.

L-Cysteine may have health benefits, but its effectiveness is still debated due to limited clinical trial data.

Notch signaling disruptions can cause various skin diseases.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Nitric Oxide has potential in medicine, especially for infections and heart treatments, but its short life and delivery challenges limit its use.