152 citations
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April 2004 in “Micron” As people age, their hair follicles produce less pigment, leading to gray and white hair, due to factors like reduced enzyme activity and damage to melanocyte DNA.
88 citations
,
September 2005 in “Journal of Dermatological Science” Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.
52 citations
,
May 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” Parathyroid hormone-related protein helps control hair growth phases in mice.
41 citations
,
December 2013 in “Experimental Dermatology” Leptin, a hormone, is important for starting hair growth.
29 citations
,
August 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” The enzymes Aldh1a2 and Aldh1a3 are involved in making retinoic acid in hair follicles and have different roles in hair growth.
9 citations
,
November 2007 in “Veterinary dermatology” Boxer and Labrador dogs' hair growth is affected by the tropical climate, but Schnauzers' is not.
6 citations
,
January 2014 in “Joint Bone Spine” Tocilizumab treatment was associated with significant hair regrowth in one patient and temporary hair loss followed by regrowth in another.
5 citations
,
January 2009 in “Dermato-endocrinology” ADAM 10 and ADAM 12 proteins are involved in different stages of hair growth and could be targets for treating hair disorders.
112 citations
,
July 1998 in “Journal of Investigative Dermatology” Ruby laser pulses best destroy hair follicles during the growth phase and effectiveness varies with laser intensity; melanin is key for targeting, and timing treatments can improve results.
375 citations
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February 2006 in “Journal of Cell Science” The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
127 citations
,
May 2008 in “Journal of Investigative Dermatology” Mice hair growth patterns get more complex with age and can change with events like pregnancy or injury.
116 citations
,
May 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.
111 citations
,
March 1951 in “Annals of the New York Academy of Sciences” Understanding the mouse hair cycle is crucial for cancer research.
103 citations
,
February 2006 in “Journal of Cell Science” The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.
67 citations
,
July 1985 in “British journal of dermatology/British journal of dermatology, Supplement” Men's thigh hair grows longer and has a longer growth cycle than women's, but arm hair growth is similar between genders.
40 citations
,
December 2011 in “British Journal of Dermatology” Women's hair generally gets thinner and less dense starting in their mid-thirties, with hair loss becoming more common as they age due to both genetics and environment.
38 citations
,
October 1988 in “Clinics in Dermatology” Hormones, nutrition, and seasonal changes regulate hair growth cycles, with androgens extending growth phases and factors like aging and malnutrition affecting hair loss and thinning.
34 citations
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May 2013 in “Journal of the European Academy of Dermatology and Venereology” Hair growth slows and shedding increases after childbirth, but most women don't experience excessive hair loss.
24 citations
,
March 1995 in “British Journal of Dermatology” Etretinate therapy can cause hair loss by disrupting the hair growth cycle.
12 citations
,
November 2014 in “PLOS Computational Biology” The study concluded that hair growth in mice is regulated by a stable interaction between skin cell types, and disrupting this can cause hair loss.
August 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” MPZL3 is important for controlling the hair growth cycle in mice and humans.
May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” MPZL3 protein is important for controlling hair growth cycles.
May 2009 in “Hair transplant forum international” Androgens affect hair growth and shedding, with genetic and non-genetic factors influencing baldness.
161 citations
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June 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair stops producing melanin as it transitions from the growth phase to the resting phase.
94 citations
,
July 2003 in “Journal of biological chemistry/The Journal of biological chemistry” EGF controls hair growth by regulating hair follicles' growth phases.
October 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Human hair follicles have a unique way of using energy and might use the Cori cycle; blocking CCR5 could help treat hair loss.
149 citations
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June 2010 in “The FASEB journal” miR-31 regulates hair growth by controlling gene expression in hair follicles.
109 citations
,
December 1998 in “The Journal of Dermatology” Manipulating the catagen and telogen phases of hair growth could lead to treatments for hair disorders.
91 citations
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May 2003 in “American Journal of Pathology” Prolactin affects hair growth cycles and can cause early hair follicle regression.
90 citations
,
October 1996 in “Dermatologic Clinics” Growth factors are crucial for hair development and could help treat hair diseases.