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The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

Menopause and aging can affect women's quality of life and sexuality, but hormone therapies may help alleviate these issues.

Keratins are important for skin cell health and their problems can cause diseases.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.

Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.

Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.

Distinct β-catenin patterns are linked to cell growth, not cell death, in lung cancer.

Pyrene excimer nucleic acid probes are promising for detecting biomolecules accurately with potential for biological research and drug screening.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

A new skin-whitening agent using a peptide from wheat is safe and effective at reducing skin pigmentation.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

The conclusion is that CD90 is not a specific marker for fibroblast subtypes and better methods are needed to identify them.

Keratin 17 is modified by RSK1 in response to growth and stress, affecting skin growth and stress response.

Enzyme replacement therapy improved multiple symptoms of homocystinuria in mice.

The document concludes that careful design of genetic fate mapping experiments is crucial for accurate cell lineage tracing in mice.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.

Mutations in certain receptors can cause diseases and offer new treatment options.

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

Mutations in the androgen receptor gene cause Androgen Insensitivity Syndrome, affecting sexual development.

FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Vesicular carriers like liposomes may improve cosmetic skin treatment delivery and effectiveness but need more human research.

Hydroxychloroquine showed some potential, but overall, the three drugs had limited success in treating lupus in dogs.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.