research Identification of Drug-Specific Public TCR Driving Severe Cutaneous Adverse Reactions
Researchers found a specific immune receptor in patients that causes severe skin reactions to a drug.
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research Auxin And Ethylene: Collaborators Or Competitors?
Auxin and ethylene hormones both work together and against each other to control plant growth.
research A Modified Laparoscopic Sleeve Gastrectomy for the Treatment of Type 2 Diabetes and Metabolic Syndrome in Obesity
Modified laparoscopic sleeve gastrectomy effectively controls diabetes and treats obesity with minimal complications.
research Critical Role of ATP-P2X7 Axis in UV-Induced Melanogenesis
ATP increases melanin production in skin after UV exposure, with the P2X7 receptor being crucial for this process.
research Critical Appraisal of Reports on the Treatment of Perioral Dermatitis
Most studies on perioral dermatitis treatment are of low quality, with some agreement on oral tetracycline effectiveness and stopping steroids and cosmetics.
research Folliculin Interacts With P0071 (Plakophilin-4) and Deficiency Is Associated With Disordered RhoA Signalling, Epithelial Polarization, and Cytokinesis
Folliculin deficiency causes problems with cell division and positioning due to disrupted RhoA signaling and interaction with p0071.
research Lack of Androgen Receptor Transcriptional Activity in Human Keratinocytes
Human keratinocytes do not naturally respond to androgens.
research Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors
Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.
research Protein Kinase C Is a Key Target for Attenuation of Leigh Syndrome by Rapamycin
Rapamycin may help treat Leigh syndrome by targeting protein kinase C.
research Finasteride Inhibits Melanogenesis Through Regulation of the Adenylate Cyclase in Melanocytes and Melanoma Cells
Finasteride reduces melanin production, possibly treating hyperpigmentation and melanoma, but needs more safety research.
research Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells
Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.
research CRISPR/Cas9-Mediated Loss of FGF5 Function Increases Wool Staple Length in Sheep
Disabling the FGF5 gene in sheep leads to longer wool.
research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications
Alopecia areata severity and treatment response are linked to specific cytokine levels.
research Botanical Extracts in Cosmetics and Pharmaceuticals: Historical Use, Regulatory Approaches, and Extraction Processes
Botanical extracts are increasingly important in cosmetics and drugs for their effectiveness and safety, backed by traditional use and scientific evidence.
research Advances in the Genetic Understanding of Hypohidrotic Ectodermal Dysplasia
Scientists now better understand the genetics of hypohidrotic ectodermal dysplasia, leading to more accurate diagnoses and potential new treatments.
research Pharmacophore and Atom-Based 3D QSAR Studies on the Novel 5-Alpha-Reductase Inhibitors
The developed model can predict effective 5-alpha-reductase enzyme inhibitors.
research Human Androgenic Steroids Affect Growth of Dermatophytes In Vitro
Androgenic steroids can slow down or stop the growth of certain skin fungi.
research Restoration of Spermatogenesis and Male Fertility Using an Androgen Receptor Transgene
Scientists restored fertility in male mice lacking a key fertility gene by using a modified gene.
research Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ
Sex hormones, especially androgens, play a key role in causing acne.
research Stimulation of Elastin Expression by Minoxidil in Chick Skin Fibroblasts
Minoxidil boosts elastin production, potentially helping skin diseases.
research Arabidopsis Retromer Subunit AtVPS29 Is Involved in SLY1-Mediated Gibberellin Signaling
AtVPS29 is essential for proper plant growth by regulating gibberellin signaling.
research Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development
The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.
research Relationship Between Exercise and Severity of Androgenic Alopecia
Regular aerobic exercise for over 60 minutes can delay and improve androgenic alopecia symptoms.
research Tfap2b Specifies an Embryonic Melanocyte Stem Cell That Retains Adult Multi-Fate Potential
The gene Tfap2b is essential for creating a type of stem cell in zebrafish that can become different pigment cells.
research Human Dermal Stem Cells Differentiate Into Functional Epidermal Melanocytes
Human dermal stem cells can become functional skin pigment cells.
research The Immunology of the Porcine Skin and Its Value as a Model for Human Skin
Porcine skin is very similar to human skin, making it a useful model for research.
research K ATP Channels and Cardiovascular Disease
K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.
research Spermidine/Spermine-N1-Acetyltransferase: A Key Metabolic Regulator
SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.
research OsPHR2 Is Involved in Phosphate-Starvation Signaling and Excessive Phosphate Accumulation in Shoots of Plants
OsPHR2 gene causes excessive phosphate in rice shoots, affecting plant growth and root development.
research Sp6 Downregulation of Follistatin Gene Expression in Ameloblasts
Sp6 promotes tooth development by reducing follistatin levels.