Canine Cutaneous Epitheliotropic T-Cell Lymphoma with Vesiculobullous Lesions Resembling Human Bullous Mycosis Fungoides

    July 2009 in “ Veterinary dermatology ”
    Petra Bizikova, Keith E. Linder, Steven E. Suter, Arnaud J. Van Wettere, Thierry Olivry
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    TLDR Vesiculobullous lesions should be considered part of canine cutaneous epitheliotropic T-cell lymphoma.
    The study described a 13-year-old male Golden Retriever mix with canine cutaneous epitheliotropic T-cell lymphoma presenting vesiculobullous lesions similar to human bullous mycosis fungoides. The dog exhibited significant weight loss and respiratory distress. Histopathology revealed large CD3+ neoplastic lymphocytes infiltrating the dermis and epidermis, with bullous lesions containing neutrophils and neoplastic cells. Clonal rearrangement analysis confirmed that skin and lung lesions originated from the same neoplastic T-cell population. The findings suggested that vesiculobullous lesions should be included in the clinical spectrum of canine cutaneous epitheliotropic T-cell lymphoma.
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