Search

everythinglearnresearchcommunity

for

Search:↓

Women with non-classical congenital adrenal hyperplasia have higher levels of certain steroids, which can be reduced by treatment.

Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.

Dried blood spots can be as stable as frozen liquid samples for storing certain metabolites.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

Androstanediol glucuronide is a reliable marker for hirsutism in women.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

DHEA did not improve sexual function, well-being, or menopausal symptoms in postmenopausal women with low libido but caused side effects like acne and increased facial hair.

Androgens significantly affect female hair loss, and hormonal treatments may help.

Taking DHEA for a year is generally safe for postmenopausal women but may cause acne and more facial hair without improving metabolism or aging.

Nano-sized plant-based chemicals could improve cervical cancer treatment by being more effective and causing fewer side effects than current methods.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

Chlormadinone acetate is a strong, well-tolerated hormone used in birth control and hormone therapy with benefits for menstrual pain and skin conditions.

Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.

Testosterone and dihydrotestosterone play a role in women's health issues like excess hair and baldness, and treatments blocking these hormones may help.

Minoxidil metabolizes similarly in monkeys and humans, but differently in dogs and rats.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

People with hair loss may have different levels of certain hormones due to changes in hormone processing.

Treatment can improve survival and symptoms in dogs with Cushing's disease, but outcomes are unpredictable.

Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.

Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.

The study found that urine metabolites M1b or M4 are the best indicators of ATD use in horses, with detection possible up to 77 hours in urine and 28 hours in blood.

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.