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The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

The document concludes that alopecia areata is an unpredictable autoimmune hair loss condition with no cure, but various treatments exist that require personalized approaches.

Biologic agents can be effective for rheumatic diseases but have risks like infections and require careful monitoring and patient information.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.

The 2003 guidelines suggest that while some treatments can regrow hair in alopecia areata, none alter the disease's progression, and wigs may be the best option for extensive hair loss.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

Imiquimod 5% cream reduced equine sarcoids in most cases.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

Finasteride may help treat chronic CSC, improving vision.

Antiandrogens, particularly flutamide and CPA, are most effective for treating hirsutism, with long-term use needed for best results.

Pregnant women often experience skin and hair changes, with over half getting stretch marks and pigment changes, and should be cautious with cosmetic procedures due to potential risks.

Cyproterone acetate plus ethinyl estradiol is generally more effective in treating hirsutism, but consider side effects and patient characteristics.

Intralesional triamcinolone acetonide is the most effective treatment for localized alopecia areata.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

Eclipta prostrata has many traditional uses and health benefits, but more research is needed to understand how it works and ensure it's safe.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

Stronger corticosteroids cause more skin damage in hairless dogs, similar to effects in humans.

Intralesional triamcinolone acetonide is effective for treating patchy hair loss, and dermoscopy helps detect treatment response and side effects early.

Finasteride and flutamide both reduce hair growth, but finasteride has fewer side effects.

Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

For women with moderate to severe unwanted hair growth or acne, birth control pills are the first choice, with other medications like cyproterone, spironolactone, flutamide, or finasteride as alternatives, and permanent hair removal should be done with electrolysis or laser.

The document concludes that ongoing research using animal models is crucial for better understanding and treating Alopecia Areata.

Most hirsutism cases are due to PCOS, and treatment focuses on lowering testosterone and blocking its effects.