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Long COVID causes a wide range of long-lasting symptoms that change over time and are hard to diagnose and treat.

More research is needed to understand how testosterone is maintained in adult males.

COVID-19 may harm male reproductive health and lower testosterone levels, potentially affecting fertility and causing erectile dysfunction. More research is needed.

No single ideal JAK inhibitor for alopecia areata has been determined; JAK3 inhibitors may be promising with fewer side effects.

The document concludes that personalized hormonal treatments are important for transgender individuals and more research is needed for non-binary treatments.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Thyroid hormones are important for skin health and might help treat skin diseases, but more research is needed to understand their effects fully.

Most women with excessive hair growth have PCOS; treatment varies and focuses on preventing new hair, with electrolysis as the only permanent removal method.

Cooling the scalp may prevent hair loss from chemotherapy, hair often grows back after treatment, and nail issues usually improve after stopping the drug.

Lower LDL-c levels predict higher COVID-19 mortality.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Steroids stop hair growth temporarily but don't block the signals that start it.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Thioredoxin reductase 1 does not affect glucocorticoid receptor activity in hair follicle cells.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

The N363S gene variant does not cause higher adrenal androgen levels in women with polycystic ovary syndrome.

High glucocorticoids cause pancreatic malfunction and malabsorption, reversible with enzyme supplements.

People with Parkinson's disease have higher levels of cortisone in their hair, which may indicate chronic stress hormone dysfunction.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

Dexamethasone increases the activity of androgen receptors in human skin cells, which may link it to certain types of hair loss.

Dexamethasone increases androgen receptor activity in scalp cells, which might explain stress-related hair loss.

Patients need better information about the risks of long-term steroid use.

Many patients with Giant Cell Arteritis did not follow their steroid treatment plans properly.