5 citations
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January 2019 in “Clinical Drug Investigation” This study found that certain off-label topical therapies, including prostaglandin analogs and polyphenols, improved hair restoration in men with androgenetic alopecia over placebo in the short term, though long-term effects are unknown.
July 2023 in “Journal of Natural Remedies” This review highlights the diverse potential medicinal properties of kavalactones from Alpinia zerumbet, which include antioxidant, anti-cancer, and anti-inflammatory activities, among others, and suggests fields for further research.
30 citations
,
February 2018 in “Journal of Pharmacy and Pharmacology” This review discusses the traditional uses and pharmacological properties of Hedychium spicatum, noting that while some traditional uses are supported by scientific studies, further research on its applications is needed.
1 citations
,
May 2017 in “InTech eBooks” This study suggests that while complementary and alternative treatments for hair loss are becoming more popular, their effectiveness and mechanisms remain largely unverified.
191 citations
,
February 2002 in “Archives of Dermatology” This review discusses herbal therapies for dermatologic disorders, focusing on those with scientific evidence of efficacy and common interactions, but reports no new clinical results.
5 citations
,
October 2025 in “International Journal of Nanomedicine” This review discusses the role of traditional Chinese medicine and bioactive materials in chronic wound healing and reports no new clinical results.
10 citations
,
September 2021 in “International Journal of Nanomedicine” This review explores the potential diagnostic and therapeutic applications of extracellular vesicles in treating various skin conditions but reports no new clinical study results.
April 2026 in “Frontiers in Physiology” This study evaluated nanovesicles derived from Polygonum multiflorum roots, finding that they promote dermal papilla cell proliferation and activate β-catenin signaling, which in turn enhances hair shaft elongation in ex vivo cultured human hair follicles, suggesting their potential use for alopecia treatment.
July 2026 in “Pharmaceuticals” This review highlights significant research trends and challenges in utilizing plant-derived extracellular vesicles for drug delivery and biomedical applications, emphasizing the need for standardized protocols and advanced purification technologies.
11 citations
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April 2025 in “Pharmaceutics” In this review, researchers explore various treatment options for alopecia, focusing on nano-drug delivery systems using plant-based substances, which are potentially effective and less harmful than current treatments, while also highlighting emerging trends such as 3D bioprinting and plant extracts for future therapies.
September 2025 in “Frontiers in Pharmacology” This study suggests that P. orientalis leaf-derived EVs could offer anxiolytic, antidepressant, and sleep-inducing benefits by affecting neurotransmitter levels and reducing inflammation, particularly when administered intranasally.
May 2026 in “Applied Biochemistry and Biotechnology” Lemon-derived vesicles may help hair grow.
June 2023 in “Frontiers in Genetics” This study suggests that the curly hair phenotype in Mangalitza pigs may involve complex gene interactions related to calcium signaling and lipid metabolism, rather than changes in TRPM2 or CYP4F3 expression.
September 2025 in “International Journal of Molecular Sciences” This review examined the potential effects of Kampo medicine Hangeshashinto on oral mucositis, highlighting that several natural products in its composition may inhibit intracellular AGEs, reduce inflammation from extracellular AGEs, and suppress cytotoxicity in stomatitis.
11 citations
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January 2024 in “Indian Journal of Pharmaceutical Sciences” This review summarizes the enhanced absorption and bioavailability of phytosome delivery systems, which combine herbal extracts with phospholipids to improve therapeutic potential, and provides an updated overview of their development, commercial availability, and patented technologies.
1 citations
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April 2022 in “Applied sciences” This study reports the development of a microemulsion using Momordica charantia extract, which demonstrated strong antioxidant and 5α-reductase inhibitory activity, potentially aiding hair loss management. The microemulsion was stable over 12 weeks, suggesting its future potential for cosmetic or pharmacological applications.
67 citations
,
November 2019 in “Molecules” This review collected findings on the various cosmetic and therapeutic properties of tea extracts, highlighting their antioxidant, anti-inflammatory, and photoprotective effects among other benefits for skin and hair care.
29 citations
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January 2021 in “Journal of Investigative Dermatology” This study demonstrates that dermal white adipose tissue regulates human hair growth and pigmentation through hepatocyte growth factor secretion, highlighting potential therapeutic targets for hair-related disorders.
3 citations
,
August 2021 in “The Open Dermatology Journal” This study found that the formulated herbal hair serum improved hair growth and hair weight with minor sensitivity after application and demonstrated stability for seven days.
January 2026 in “Frontiers in Nutrition” This study found that various dietary supplements positively impacted hair density and were well-tolerated among patients with androgenetic alopecia, suggesting they may be useful adjuncts or alternatives to standard treatments.
January 2024 in “Indian Journal of Pharmaceutical Sciences” This study hypothesizes that the curling of hair may result from the contraction of the Arrector Pili Muscle, contributing to the diverse types of curly hair.
January 2024 in “Indian Journal of Pharmaceutical Sciences” This study hypothesizes that curly hair is shaped by the contraction of the Arrector Pili Muscle within the follicle, potentially modifiable through muscle-relaxing treatments, but further research is needed to confirm this mechanism.
14 citations
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November 2012 in “SLAS discovery” This study observed that certain herbal extracts may promote hair growth and inhibit hair loss in cell lines by affecting specific protein expressions similarly to minoxidil.
39 citations
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June 2017 in “Journal of Applied Research on Medicinal and Aromatic Plants” This review examines around 68 plant sources from six major plant families, assessing their scientific rationale and use by the cosmeceutical industry for applications like anti-ageing and sun protection.
17 citations
,
April 2015 in “Tropical Journal of Pharmaceutical Research” This review highlights the traditional use and potential therapeutic activities of Asiasari Radix in drug discovery, but it reports no new clinical results.
8 citations
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January 2014 in “BioMed Research International” This study reported that among three plant extracts tested for hair growth on nude mice, Eclipta alba significantly increased hair density and length, unlike Asiasari radix and Panax ginseng.
April 2024 in “MGM Journal of Medical Sciences” This study outlines several common home remedies used in India, such as turmeric, ginger, and coconut, highlighting their traditional efficacy in treating minor ailments and emphasizing the importance of balancing traditional and modern medicine for optimal health outcomes.
48 citations
,
April 2023 in “Aging Cell” This review discusses cellular senescence in human skin, detailing both beneficial and detrimental effects and suggesting the potential for therapies targeting senescence-related skin disorders, but reports no new clinical results.
February 2026 in “Molecular and Cellular Probes” This systematic review synthesizes evidence from the past 20 years to highlight the potential of exosome-based therapies from stem cells and plants in improving cutaneous repair, skin aging, and challenging dermatological conditions through mechanisms like immunomodulation and collagen remodeling.
46 citations
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October 2025 in “Journal of Nanobiotechnology” This review examines the potential of plant-derived exosome-like nanovesicles in dermatology, highlighting their bioactive properties and discussing challenges to their clinical application, but does not provide new clinical results.