Potential of Natural Products in Hangeshashinto Water Extract on the Direct Suppression of Stomatitis Induced by Intra-/Extracellular Advanced Glycation End-Products

September 2025 in “ International Journal of Molecular Sciences ”

Takanobu Takata, Junji Moriya, Katsuhito Miyazawa, Shinya Inoué, Sohsuke Yamada, Jia Han, Qian Yang, Xin Guo, Shuichi Mizuta, Takeshi Nakahashi, Nobuyuki Onai, Hiroyuki Nakano, Togen Masauji, Yoshiharu Motoo

Hangeshashinto advanced glycation end-products AGEs glycyrrhizin baicalin quercetin RAGE TLR4

Studysummary This review examined the potential effects of Kampo medicine Hangeshashinto on oral mucositis, highlighting that several natural products in its composition may inhibit intracellular AGEs, reduce inflammation from extracellular AGEs, and suppress cytotoxicity in stomatitis.

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The review investigates the potential of natural products in Hangeshashinto water extract to suppress stomatitis by targeting advanced glycation end-products (AGEs). It identifies 19 natural products in the extract and 16 in the crude drug extract, which inhibit AGE formation and suppress AGE-induced inflammation. Compounds like glycyrrhizin, baicalin, and quercetin are highlighted for their roles in inhibiting intracellular AGE generation and extracellular AGE-RAGE/TLR4 signaling. The study suggests that these natural products could protect oral epithelial cells and manage stomatitis linked to AGEs, although further research is needed to fully understand their mechanisms and efficacy.

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research Real-World, Open-Label Study of the Efficacy and Safety of a Novel Serum in Androgenetic Alopecia

May 2023 in “Journal of Drugs in Dermatology”

This study reported that the novel topical serum REVIVV®, containing a blend of phytochemicals, significantly improved hair growth and reduced shedding in 150 participants with androgenetic alopecia after 8 weeks of use, while also being rated easy to use and prompting plans for continued use.