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Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Rhodococcus equi causes severe pneumonia in young foals, and effective vaccines are needed due to foals' weak immune responses.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

New antifungal treatments for a children's scalp infection are effective and safe, but it's not decided if they will become the preferred option over the old treatment.

Blocking the virus's entry into cells by targeting certain pathways could lead to early COVID-19 treatments.

The document concludes that more research is needed to understand how to treat muscle pain with drugs.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.

Negative expectations can cause adverse effects in patients even without active treatment, and managing this nocebo effect involves better communication and patient-clinician relationships.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

Adrenal disorders can cause lasting brain and behavior issues in children.

Common acne treatments can cause various side effects, like skin irritation and more serious issues, but combination therapies are often more effective and better tolerated.

Bimatoprost is promising for treating some types of hair loss but needs more testing for androgenetic alopecia.

Bariatric surgery may help severely obese teenagers but has risks and requires careful patient selection and long-term care.

Skin diseases, especially psoriasis, greatly affect people's quality of life, similar to chronic diseases.

Stress can worsen skin conditions and affect mental health, so doctors should include stress management in skin treatment.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Eating less starch and dairy helped overweight women with PCOS lose weight and improve symptoms.

Alopecia areata causes hair loss due to an immune attack on hair follicles, influenced by genetics and environment.

Menopausal acne is treated with medications and lifestyle changes, but careful choice is needed due to side effects.

Centipeda minima extract helps hair grow by activating important growth signals and could be a promising hair loss treatment.

Many adults in Porto have acne, but few know or treat it.

The conclusion is that more research is needed to better understand and treat adult acne, and that patient education and simple treatment plans are important for better results.

New treatments for skin and hair disorders in women of color address unique biological differences and include specific acne medications, sunscreens, skin lighteners, and hair care adjustments.

Tiny particles called anionic squarticles can effectively remove a common antidepressant from the body after an overdose.

Effective symptom management in IBD improves quality of life and prevents complications.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.