Infant Alopecia Universalis: Role of Topical PUVA (Psoralen Ultraviolet A) Radiation

An 11-month-old boy with alopecia universalis was treated with topical PUVA radiation and 0.03% tacrolimus ointment, resulting in complete hair regrowth on the scalp, eyebrows, and eyelashes within 3 months. The treatment involved twice-weekly PUVA for the scalp and twice-daily tacrolimus for the eyebrows, with a total UVA exposure of 68 j/cm² over 36 treatments. No side effects were observed, and there was no recurrence during a 6-month follow-up, suggesting that topical PUVA could be an effective and safe treatment for AU in infants.