Solid Lipid Nanoparticles: A Promising Technology for Delivery of Poorly Water-Soluble Drugs
January 2018
in “
Acta pharmaceutica sciencia
”
TLDR Solid lipid nanoparticles can improve how well drugs that don't dissolve in water work and are safe.
Six years ago, a study from MM College of Pharmacy and MM University in India explored the potential of Solid Lipid Nanoparticles (SLN) as a drug delivery system for poorly water-soluble drugs. The researchers found that SLN could enhance the solubility, stability, permeability, and bioavailability of these drugs, with minimal side effects. This technology was particularly beneficial for oral administration, overcoming enzymatic barriers in the gastrointestinal tract that often hinder the effectiveness of such drugs. The study also highlighted the potential applications of SLN in treating various diseases, including tuberculosis, cancer, diabetes, and several nervous system-related disorders.