TLDR Solid lipid nanoparticles can improve how well drugs that don't dissolve in water work and are safe.
Six years ago, a study from MM College of Pharmacy and MM University in India explored the potential of Solid Lipid Nanoparticles (SLN) as a drug delivery system for poorly water-soluble drugs. The researchers found that SLN could enhance the solubility, stability, permeability, and bioavailability of these drugs, with minimal side effects. This technology was particularly beneficial for oral administration, overcoming enzymatic barriers in the gastrointestinal tract that often hinder the effectiveness of such drugs. The study also highlighted the potential applications of SLN in treating various diseases, including tuberculosis, cancer, diabetes, and several nervous system-related disorders.
12 citations,
January 2018 in “Journal of Drug Delivery Science and Technology” The new particle system could be a promising treatment for diseases related to the 5-α reductase enzyme.
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47 citations,
September 2015 in “Journal of Drug Delivery Science and Technology” Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.
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39 citations,
September 2016 in “Expert Opinion on Drug Delivery” New drug delivery methods can make natural compounds more effective and stable.
February 2024 in “International Journal For Multidisciplinary Research” Nanostructured lipid carriers are effective for treating hyperpigmentation in women aged 30-40.
December 2013 in “Biomedical and biopharmaceutical research” Nanotechnology shows promise for better drug delivery and cancer treatment.
151 citations,
November 2018 in “International Journal of Pharmaceutics” Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.
December 2024 in “Pharmaceutics” Spironolactone nano-formulations show promise for treating skin disorders, but more research is needed for safety and effectiveness.
