October 2024 in “Frontiers in Pharmacology” This study found that in patients with genetic generalized epilepsies, certain gene variants were linked to differences in valproic acid treatment outcomes, including a higher likelihood of treatment failure, varying serum drug concentrations, and specific side effects like weight gain and hair loss.
72 citations
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November 2002 in “Journal of Investigative Dermatology” Estrogen receptor α controls hair growth cycles and skin thickness in male mice.
July 2025 in “Frontiers in Pharmacology” This study highlights the potential of GPR30 and its selective agonists as promising therapeutic targets for treating hair loss disorders and conditions that respond to estrogen, emphasizing their role in modulating hair growth.
131 citations
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September 2017 in “Molecular and Cellular Endocrinology” This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.
August 2025 in “Aesthetic Plastic Surgery” This review explores the mechanisms, current products, challenges, and innovative approaches related to cosmetics for hair loss prevention and growth promotion, emphasizing the need for multidisciplinary cooperation to enhance product development and market success.
March 2025 in “Clinical Cosmetic and Investigational Dermatology” In this study, researchers found that the "U" allele of the Tru9I variant may be associated with low vitamin D levels and altered VDR gene activity in alopecia areata patients, while the "u" allele might have a protective role against developing the condition.
46 citations
,
January 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Insig deficiency in the skin of mice causes cholesterol precursors to accumulate, leading to defective hair development and skin abnormalities, which were alleviated by simvastatin treatment.
8 citations
,
February 2025 in “Pharmaceuticals” This source reviews the potential of polyphenols as therapeutic and preventive treatments for common skin disorders such as acne, fungal infections, dermatitis, alopecia, and skin cancer, emphasizing their anti-inflammatory and antimicrobial effects and ability to penetrate the skin barrier.
February 2013 in “Journal of the American Academy of Dermatology” In this study, the HairCheck device was reported to accurately assess changes in hair density and diameter, suggesting its usefulness in monitoring alopecia progression and treatment response.
5 citations
,
January 2014 in “BioMed Research International” This collection of papers reviews recent research on women's skin, focusing on hormonal influences, environmental impacts, and specific skin disorders, with no new clinical results reported.
1 citations
,
October 2023 in “Life science alliance” This study observed that pantethine, a vitamin B5 precursor, attenuates tumor growth in immunocompetent mice by enhancing antitumor immunity, but its effect is limited by immune cell exhaustion over time.
34 citations
,
September 2020 in “BMC Endocrine Disorders” This review highlights that while dexamethasone may reduce mortality in severe COVID-19, no other drugs have proven effectiveness for treatment, emphasizing the need for clinical trials of existing medications.
1 citations
,
June 2012 in “Springer eBooks” This article discusses the potential of acupuncture as a complementary or alternative therapy for PCOS, highlighting experimental evidence of its positive effects on reproductive and metabolic function, but reports no new clinical results.
19 citations
,
July 2015 in “Journal of inherited metabolic disease” This study observed that while betaine supplementation decreases total homocysteine and increases methionine levels in a mouse model of CBS deficiency, it is not as effective as methionine restriction in reversing associated phenotypes.
34 citations
,
March 2020 in “BMC plant biology” This study found that cotreatment with graphene oxide and indole-3-acetic acid significantly inhibited root development in Brassica napus, with the inhibition increasing as indole-3-acetic acid concentration rose.
24 citations
,
July 2018 in “Stem cells” This study found that Runx1 in hair follicle stem cells modulates lipid metabolism, impacting membrane organization and enhancing signal transduction for cell proliferation in both normal and cancer epithelial cells.
8 citations
,
December 2022 in “Nature Reviews Endocrinology” This review discusses the roles of sex hormones in COVID-19 progression and highlights conflicting evidence on their protective effects and the complexity of sex and gender influences on the disease.
227 citations
,
April 2020 in “Cell” This review highlights the ongoing challenges and advancements in developing precise and early intervention strategies for autoimmune diseases and emphasizes the need for more personalized and disease-specific therapies.
1 citations
,
January 2025 in “Journal of Fungi” This narrative review and case report identified a rare association between erythema nodosum and kerion caused by *Trichophyton mentagrophytes*, with successful treatment using antifungals and corticosteroids.
This study found that combining finasteride and anastrozole was more effective in preventing and treating benign prostatic hyperplasia in rats than using either drug alone.
1 citations
,
July 2018 in “Elsevier eBooks” This review covers androgenetic alopecia's epidemiology, pathogenesis, current management options, and research trends, concluding that no definitive cure exists despite extensive interest and ongoing genetic research efforts.
57 citations
,
January 1986 in “The Prostate” This article discusses the role of dihydrotestosterone in human prostatic adenocarcinoma growth and suggests that 6-methyleneprogesterone could be used to inhibit DHT for treating hormone-responsive prostate cancer, without new clinical findings.
278 citations
,
May 2013 in “Ca” This review discusses the shift in toxicity profiles of cancer therapies from traditional chemotherapy to targeted agents, noting similar overall toxicities but with different side effects, and reports no new findings.
31 citations
,
November 2000 in “Journal of the European Academy of Dermatology and Venereology” This article discusses the diverse dermatological symptoms associated with sexual abuse, highlighting the challenges in establishing causal links and the potential long-term psychosomatic manifestations, without reporting new research results.
13 citations
,
January 2019 in “Endocrine journal” This study found that transdermal DHT treatment increased penile length in boys with 5α-reductase type 2 deficiency, but post-pubertal growth was limited and carried potential prostate complications.
April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study analyzed social media posts and found discrepancies between patient-reported satisfaction and emotional responses to alopecia areata treatments, highlighting potential gaps between perceived and clinical efficacy.
July 2026 in “International Journal of Innovative Technologies in Social Science” This review found that while treating keratosis pilaris is challenging, current therapies can lead to significant improvement, particularly when tailored to the individual's specific disease phenotype and concerns.
52 citations
,
October 1999 in “Developmental Dynamics” This study found that the hairless gene in mice has a more extensive role in development than previously thought, as indicated by its expression in various tissues and associated abnormalities in hr/hr mutants.
37 citations
,
February 2010 in “Psychoneuroendocrinology” This study found that nuclear androgen receptors are not necessary for androgen self-administration, suggesting that plasma membrane receptors might be involved.
3 citations
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June 2017 in “Reproductive biomedicine online” In this study, the SRD5A2 rs523349 polymorphism was significantly associated with an increased risk of miscarriage, particularly during the second trimester.