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The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

The study found that diseases can be grouped by symptoms and that the accuracy of predicting disease-related genes varies with the data source.

The document concludes that transplantology has evolved with improved techniques and materials, making transplants more successful and expanding the types of transplants possible.

The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.

The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.

Genetically-altered adult stem cells can help in wound healing and are becoming crucial in regenerative medicine and drug design.

Single-cell engineered biotherapeutics show promise for skin treatment but need more research and trials.

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

Advanced human skin models improve drug development and could replace animal testing.

Melatonin directly affects mouse hair follicles and may influence hair growth.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

The document concludes that the technique allows for the detection of LDH activity in various tissues, showing where cells are actively metabolizing glucose.

Blocking both main energy pathways can stop hair follicle stem cell-induced skin cancer growth.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

RNAi-based biopesticides could be safe and effective for pest control with careful development and risk assessment.

A gene variant causes patched hair loss in mice, similar to alopecia areata in humans.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.

Altered metabolism can help control seizures by changing brain signaling and energy use, suggesting new treatments for epilepsy.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.

The conclusion is that accurately replicating the complexity of the extracellular matrix in the lab is crucial for creating realistic human tissue models.

The mouse hairy ears mutation causes longer ear hair due to changes in gene expression.

The project created a standardized system for classifying skin lesions in lab rats and mice.

A gene mutation causes early keratinocyte maturation leading to hair loss in Olmsted syndrome.

Human skin xenografting could improve our understanding of skin development, renewal, and healing.