Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, Trf1 genetic deletion in mice, including those with cancer-prone mutations, was shown to not affect overall viability and cause only mild effects, while being necessary for tumor formation, suggesting a potential therapeutic window for Trf1 as an anti-cancer target.

This study found that C57BL/6 mice and Sprague–Dawley rats show distinct distributions of eccrine sweat glands and hair follicles in their volar skin, suggesting these models should be selected according to research focus on skin appendages.

This review discusses genetic skin diseases in humans and animals, offering a resource for memorization and exploring animal models' role in understanding human disease mechanisms; it reports no new clinical results.

In this study, researchers identified genes IRF2BP2 and EGFR as key to understanding double-coated fleece formation in Hetian sheep, offering insights that may advance machine learning-driven multi-omics selection models in sheep breeding.

This study found that homozygous mutant mice with a hypomorphic CD18 mutation developed a chronic inflammatory skin disease resembling human psoriasis, potentially implicating additional genetic factors in disease susceptibility.

This study found that a laboratory model using nude mice can produce human hair follicles with amino acid compositions resembling both normal and trichothiodystrophy-affected human scalp hair over extended periods.

In this study, researchers developed a new photoactivatable Cre recombinase mouse model, DiLiCre, which allows precise light-induced genetic modifications and cell tracing, demonstrating its effectiveness for advancing biological and biomedical research.

This review discusses a "stochastic multi-hit model" to explain the onset, progression, and recurrence of vitiligo and other autoimmune skin diseases, emphasizing genetic and environmental influences, immune cell interactions, and unexplored mechanistic gaps.

This study identified a novel recessive mutation in mice causing lethal congenital lamellar ichthyosis, with skin and hair follicle alterations similar to human congenital ichthyoses, linked to a specific genetic defect affecting Fatp4.

This review found that current forensic DNA phenotyping panels for biogeographical ancestry and visible traits face significant limitations due to inconsistencies in terminology, genetic understanding, and genotyping technologies, highlighting the need for harmonization and further research.

This review discusses existing forensic DNA phenotyping panels for biogeographical ancestry and externally visible characteristics and highlights major technical limitations, including terminology issues, genetic knowledge gaps, and technological debates; it reports no new results.

This review discusses the limitations of animal models, particularly mice, in accurately predicting human skin wound healing outcomes and emphasizes understanding species-specific differences in skin characteristics for better translation to clinical settings.

This article discusses a proposed "Darwinian" model of carcinogenesis and emphasizes that cancer prevention involves more than avoiding mutagens, as gene-environment interactions are complex and non-linear.

This study proposed a model that accurately predicts skin condition using genotype information and machine learning, suggesting potential for creating customized cosmetics.

This study applied a prediction model based on five SNPs to Russian males with male pattern hair loss, finding a significant association between the AR genomic region and high dihydrotestosterone levels in these patients.

This study utilized the Random Forest Algorithm to create a machine learning model aimed at accurately predicting hair loss by considering complex datasets involving genetic, hormonal, lifestyle, and environmental factors, but specific outcomes were not reported.

This study identified two novel genetic variants associated with Alzheimer's disease in APOE ε4 non-carriers, revealing insights into the disease's underlying regulatory mechanisms.

This review summarizes studies on knockout mouse models revealing abnormalities in skin and hair follicle development but reports no new experimental results; the authors highlight the utility of these models for understanding hereditary skin disorders.

This study developed a 3D ovarian cancer model using microtumours, which effectively mimics minimal residual disease and supports the identification of new drug targets like perhexiline for treatment-resistant cells.

This study highlights multiple factors contributing to hair graying, such as oxidative damage, melanocyte changes, and genetic influences, and suggests that repigmentation may be temporarily reversible, offering potential targets for future treatments while urging caution when applying mouse model findings to humans.

This study found that genetic ablation of Tslp in an AEC mutant mouse model reduced skin inflammation and improved survival, suggesting potential therapeutic benefits for AEC syndrome patients.

This review explores the biology of wool follicles and suggests their potential use as research models in modern biology, but it reports no new findings.

This review discusses the role of Hedgehog signaling in basal cell carcinoma development and highlights genetic mouse models and potential targeted therapies, but reports no new clinical results.

This article reviews the genetic and potential environmental factors in alopecia areata's pathogenesis and suggests a polygenic model but reports no new clinical findings.

This study reports that an Explainable AI-based hair health prediction system using a novel hybrid model outperformed traditional machine learning methods, achieving high accuracy in predicting key factors and providing personalized recommendations.

This study found that individuals with early onset extensive androgenetic alopecia have an elevated ratio of DHT to testosterone, but no significant genetic linkage to markers on chromosomes 2 or 5 was detected.

This review discusses recent genetic approaches to understanding tissue regeneration mechanisms in vertebrates and reports no new results; it highlights objectives in identifying cellular and molecular factors involved.

This review discusses the state-of-the-art knowledge on pseudoxanthoma elasticum, summarizing recent advancements in genetics, pathomechanisms, and potential treatments but reports no new clinical findings.

This review discusses the molecular mechanisms of Hutchinson-Gilford progeria syndrome and evaluates current research trends, available mouse models, and prospects for developing therapies, but reports no new clinical findings.

This study found that Hoxc13-/- rabbits exhibit complete hair loss on the head and dorsum, providing a potential model for understanding human ECTD-9 and related dermatological conditions.