Machine Learning Driven Multi-Omics Analysis of the Genetic Mechanisms Behind the Double-Coat Fleece Formation in Hetian Sheep

    June 2025 in “ Frontiers in Genetics ”
    Yanwei Zhang, Wenrong Li, Xinming Xu … Jiang Di
    Studysummary In this study, researchers identified genes IRF2BP2 and EGFR as key to understanding double-coated fleece formation in Hetian sheep, offering insights that may advance machine learning-driven multi-omics selection models in sheep breeding.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on frontiersin.org →
    Discuss this study in the Community →

    Research cited in this study 12

    1. Analysis of Differential Expression of Hair Follicle Tissue Transcriptome in Hetian Sheep Undergoing Different Periodic Changes PeerJ · 2024
    2. Proteome Analysis of Alpine Merino Sheep Skin Reveals New Insights into the Mechanisms Involved in Regulating Wool Fiber Diameter International journal of molecular sciences · 2023
    3. Identification of Key Genes and Signaling Pathways Related to Hetian Sheep Wool Density by RNA-Seq Technology PLOS ONE · 2022
    4. Comprehensive Transcriptome and Methylome Analysis Delineates the Biological Basis of Hair Follicle Development and Wool-Related Traits in Merino Sheep BMC Biology · 2021
    5. TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cells on Hair Follicle Regeneration Frontiers in Pharmacology · 2021
    6. Analysis of lncRNAs Expression Profiles in Hair Follicles of Hu Sheep Lambskin Animals · 2020
    7. Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat Cells · 2020
    8. EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner iScience · 2019
    9. Comparative Study on Seasonal Hair Follicle Cycling by Analysis of the Transcriptomes from Cashmere and Milk Goats Genomics · 2019
    10. The Epidermal Growth Factor Receptor Decreases Stathmin 1 and Triggers Catagen Entry in the Mouse Experimental dermatology · 2015
    11. Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015
    12. Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003