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The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Follistatin helps hair growth and cycling, while activin prevents it.

White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.

The p53 protein helps control hair follicle shrinking by promoting cell death in mice.

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.

Scientists found cells in hair that are key for growth and color.

Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.

The document concludes that careful design of genetic fate mapping experiments is crucial for accurate cell lineage tracing in mice.

HPV16 oncogenes disrupt the normal activity of hair follicle stem cells.

Mice can regenerate ear tissue without the p53 protein.

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.

Celsr1 is crucial for skin cell alignment, while Celsr2 has little effect on this process.

Dermal EZH2 controls skin cell development and hair growth in mice.

Removing centrosomes from skin cells leads to thinner skin and stops hair growth, but does not greatly affect skin cell differentiation.

Acupuncture may improve reproductive and metabolic functions in PCOS without negative side effects, but more research is needed to confirm its effectiveness.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Ezh2 controls skin development by balancing signals for dermal and epidermal growth.

Dermal EZH2 controls skin cell growth and differentiation in mice.

C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.

Vitamin D Receptor is crucial for normal skin and hair growth.

Low selenium levels can extend lifespan but worsen health issues.

Get3d protein helps maintain photosynthesis in plants and photosynthetic bacteria.

Both estrogens and androgens are important for health in both males and females.