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Alopecia in animals can be hereditary, congenital, or acquired, with treatments and outcomes varying widely.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

Noggin is necessary to start the hair growth phase in skin after birth.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Stem cell niches support, regulate, and coordinate stem cell functions.

Cathepsin L is essential for normal hair growth and development.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.