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GlossaryFollicular Dystrophy

condition where hair follicles are damaged, causing abnormal hair growth

Follicular Dystrophy refers to a condition where hair follicles are damaged or malformed, leading to abnormal hair growth or hair loss. This can result from genetic factors, trauma, or underlying medical conditions, and often manifests as brittle, fragile hair that breaks easily.

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research Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans

56 citations, September 2010 in “Veterinary pathology”

Certain mouse strains develop a skin condition similar to a human hair loss disease due to genetic defects.

research Hair Follicle Dystrophy in a Litter of Domestic Cats Resembling Lanceolate Hair Mutant Mice

3 citations, January 2021 in “Veterinary dermatology”

A litter of cats had a hair condition similar to a mouse mutation, leading to hair loss and abnormal hair and skin.

Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

47 citations, April 2000 in “The American journal of pathology”

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

research Lanceolate Hair-J (LahJ): A Mouse Model for Human Hair Disorders

37 citations, June 2000 in “Experimental dermatology”

The Lanceolate hair-J mutation in mice mimics human hair disorders like Netherton's syndrome.

research Sebaceous Gland Abnormalities in Fatty Acyl CoA Reductase 2 (Far2) Null Mice Result in Primary Cicatricial Alopecia

14 citations, October 2018 in “PloS one”

Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.

research The Near-Naked Hairless Mutation Disrupts Hair Formation but Is Not Due to a Mutation in the Hairless Coding Region

8 citations, March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

The near-naked hairless mutation causes hair loss but is not due to a mutation in the hairless gene itself.

research Two Hypomorphic Alleles of Mouse Ass1 as a New Animal Model of Citrullinemia Type I and Other Hyperammonemic Syndromes

35 citations, August 2010 in “The American journal of pathology”

Researchers created a new mouse model for studying Citrullinemia Type I and similar conditions, showing symptoms and treatment responses like those in humans.

Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation

research Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation

19 citations, November 2018 in “Nutrients”

Annurca apple extract may protect mouse hair from damage by chemotherapy and could help treat hair loss without promoting cancer growth.

research DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization

22 citations, November 2016 in “International journal of molecular sciences”

Vitamin D receptor is important for regulating hair growth and wound healing in mice.

research Retinoids Putting the 'A' in Alopecia

7 citations, January 2013 in “Journal of Investigative Dermatology”

Vitamin A may influence hair loss conditions like alopecia, but more research is needed to understand how.

research Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis

32 citations, June 2013 in “Journal of Investigative Dermatology”

Mice without certain skin proteins had abnormal skin and hair development.

Antisense Oligonucleotide Targeting Fibroblast Growth Factor Receptor-1 Stimulates Cellular Activity of Hair Follicles in an In Vitro Organ Culture System

research Antisense Oligonucleotide Targeting Fibroblast Growth Factor Receptor-1 Stimulates Cellular Activity of Hair Follicles in an In Vitro Organ Culture System

7 citations, March 2007 in “International Journal of Dermatology”

Targeting FGFR-1 with antisense oligonucleotides may help treat baldness by increasing hair follicle activity.

research Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia

179 citations, June 2000 in “The American journal of pathology”

The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.

research Autosomal Recessive Monilethrix: Novel Variants of the DSG4 Gene in Three Chinese Families

5 citations, February 2022 in “Molecular genetics & genomic medicine”

New gene variants linked to a rare inherited hair loss disorder were found in three Chinese families.

research Retinoid Metabolism Is Altered in Human and Mouse Cicatricial Alopecia

22 citations, October 2012 in “Journal of Investigative Dermatology”

Altered retinoid metabolism in cicatricial alopecia suggests a balanced vitamin A diet may prevent the condition.

research Focal Alopecia in Dogs

August 2017 in “Companion animal”

Focal alopecia in dogs has many causes and requires various tests for accurate diagnosis and treatment.

research Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice

53 citations, May 2010 in “Journal of Cellular Physiology”

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

research Trichodysplasia of Immunosuppression Treated with Oral Valganciclovir

41 citations, December 2008 in “Journal of the American Academy of Dermatology”

Oral valganciclovir improved a patient's skin condition caused by immunosuppression.

research Canine Noninflammatory Alopecia: A Comprehensive Evaluation of Common and Distinguishing Histological Characteristics

28 citations, May 2012 in “Veterinary Dermatology”

Different types of dog hair loss are linked to problems starting the hair growth phase and early hair cycle ending.

research T-Cell Reconstitution After Thymus Xenotransplantation Induces Hair Depigmentation and Loss

7 citations, January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

T-cell reconstitution after thymus transplantation can cause hair whitening and loss.

research Alopecia

January 2018 in “Elsevier eBooks”

The document concludes that alopecia has significant social and psychological effects, leading to a market for hair loss treatments.

Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts

research The C3H/HeJ Mouse and DEBR Rat Models for Alopecia Areata: Review of Preclinical Drug Screening Approaches and Results

59 citations, September 2008 in “Experimental dermatology”

Both mouse and rat models are effective for testing alopecia areata treatments.

research A Splice Variant in KRT71 Is Associated with Curly Coat Phenotype of Selkirk Rex Cats

40 citations, June 2013 in “Scientific Reports”

A gene variant in KRT71 causes the curly fur in Selkirk Rex cats.

research Oral Zinc Sulphate Causes Murine Hair Hypopigmentation And Is A Potent Inhibitor Of Eumelanogenesis In Vivo

30 citations, June 2006 in “British journal of dermatology/British journal of dermatology, Supplement”

Oral zinc sulphate reduces dark hair color in mice.