In Vivo Immunological Toxicity in Mice of Carbon Nanotubes with Impurities

January 2009 in “ Carbon ”

Shozo Koyama, Yoong Ahm Kim, T. Hayashi, Kenji Takeuchi, Chifumi Fujii, Naomi Kuroiwa, Haruhide Koyama, Tamotsu Tsukahara, Morinobu Endo

alopecia

TLDR Pure carbon nanotubes are safe for mice, but impure ones cause immune issues and hair loss.

The study investigated the immunological toxicity of carbon nanotubes with impurities in mice by monitoring changes in peripheral T-cell subsets, cytokine levels, and histology. Mice implanted with contaminated tubes exhibited immunological toxicity and localized alopecia, while those with extremely pure tubes showed good biocompatibility. The findings suggested that high-temperature thermal treatment effectively improved the biocompatibility of carbon nanotubes.

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Research cited in this study

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In Vivo Immunological Toxicity in Mice of Carbon Nanotubes with Impurities

Research cited in this study

research Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-Mediated Root Sheath Disruption in Advance of Overt Hair Loss

research Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata

research Alopecia Areata in Aging C3H/HeJ Mice

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