In Vivo Immunological Toxicity in Mice of Carbon Nanotubes with Impurities

    January 2009 in “ Carbon ”
    Shozo Koyama, Yoong Ahm Kim, T. Hayashi, Kenji Takeuchi, Chifumi Fujii, Naomi Kuroiwa, Haruhide Koyama, Tamotsu Tsukahara, Morinobu Endo
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    TLDR Pure carbon nanotubes are safe for mice, but impure ones cause immune issues and hair loss.
    The study investigated the immunological toxicity of carbon nanotubes with impurities in mice by monitoring changes in peripheral T-cell subsets, cytokine levels, and histology. Mice implanted with contaminated tubes exhibited immunological toxicity and localized alopecia, while those with extremely pure tubes showed good biocompatibility. The findings suggested that high-temperature thermal treatment effectively improved the biocompatibility of carbon nanotubes.
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