Hair Follicle Dystrophy in a Litter of Domestic Cats Resembling Lanceolate Hair Mutant Mice

January 2021 in “ Veterinary dermatology ”

Ana Rostaher, S. V. Bettenay, Lisa Specht, Kathleen A. Silva, Lesley Bechtold, Chen Chen Jiang, M. Majzoub, Ralf S. Mueller, John P. Sundberg

hair follicle dystrophy lanceolate hair noninflammatory alopecia trichothiodystrophy hair shaft abnormalities skin abnormalities sulfur content hair tip defects hair loss hair defects

TLDR A litter of cats had a hair condition similar to a mouse mutation, leading to hair loss and abnormal hair and skin.

The study described a rare congenital hair shaft anomaly in a litter of four domestic shorthair (DSH) cats, which resembled the lanceolate hair phenotype seen in certain mutant mice. The affected cats exhibited progressive, non-inflammatory alopecia. Histopathological evaluation, transmission electron microscopy, and X-ray element analysis revealed structural defects in the hair shafts and follicles, including swollen hair shafts and a significant reduction in sulfur content, indicative of trichothiodystrophy. These findings were comparable to those observed in mutant mice with specific genetic mutations in adhesion or keratin genes. The study highlighted a unique form of congenital alopecia resulting in follicular dystrophy in cats.

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Hair Follicle Dystrophy in a Litter of Domestic Cats Resembling Lanceolate Hair Mutant Mice

Research cited in this study

research A Case of Pili Torti in a Young Adult Domestic Short-Haired Cat

research Keratin 71 Mutations: From Water Dogs to Woolly Hair

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research Hair Loss Disorders in Domestic Animals

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research Structural and Molecular Hair Abnormalities in Trichothiodystrophy

research Desmoglein 4 Mutations Underlie Localized Autosomal Recessive Hypotrichosis in Humans, Mice, and Rats

research FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice

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research Cross-Linked Features of Mouse Pelage Hair Resistant to Detergent Extraction

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