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The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Removing part of the vitamin D receptor stops vitamin D from working properly.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Nerves are crucial for the regeneration of various body parts in many animals.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Sebocytes play a key role in controlling androgen levels in human skin.

Targeted cancer therapies often cause serious skin problems that need careful management.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Oestrogens are key for bone growth during puberty in both boys and girls.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Too much androgen can cause hair loss; finasteride may help.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

Finasteride effectively treats baldness but may cause sexual side effects.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

A WNT10A gene mutation leads to ectodermal dysplasia by disrupting cell growth and differentiation.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

Improving skin barrier and using antifungal treatments can help manage dandruff.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.