1 citations
,
May 2026 in “Signal Transduction and Targeted Therapy” This review highlights the promising role of stem cell therapy in treating resistant diseases, while also addressing the challenges in production and clinical application, emphasizing the need for standardized manufacturing and quality assurance to enhance efficacy and safety in clinical translational research.
1 citations
,
April 2025 in “Scientific Reports” This study developed a culture method to expand and differentiate primary mammary basal cells, identifying key transcription factors like EGR1 and ELF3 that influence Claudin expression and actin organization, offering insights into epithelial cell biology and potential applications in related research fields.
1 citations
,
November 2015 This study observed that human dental pulp stem cells can differentiate into adipocytes and osteocytes, but their potential for neural differentiation remains uncertain due to similar responses seen in undifferentiated cells.
1 citations
,
July 2007 in “Regenerative Medicine” Stem cell research and regenerative medicine have made significant advancements in treating various diseases and conditions.
July 2026 in “Organoid Research” In this review, researchers summarize key factors in constructing skin organoids, including cell source and assembly methods, and emphasize advances such as air-liquid interface culture for improving tissue development, aiming to guide standardized protocols and future clinical applications.
April 2026 in “Nature Communications” This study found that dedifferentiated corneal epithelial cells can revert to a stem-cell-like state, aiding tissue homeostasis and repair, with this plasticity limited to the epithelial lineage and enhanced by niche-derived cytokines.
January 2026 in “Drug Delivery and Translational Research” This study investigated the integration of crystal engineering and microneedle technology for androgenetic alopecia treatment, finding that microneedles loaded with newly developed Kopexil multicomponent crystals reduced drug diffusion rates in vitro compared to standard formulations.
March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reports that transplantation and in vivo reprogramming using specific reprogrammed cell types can generate skin appendage-like structures in adult mice, suggesting potential therapeutic avenues for skin regeneration and disorders.
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that inducing miR-205 reduces actin contractility and stiffness in hair follicle stem cells and progenitors, stimulating hair regeneration in both young and old mice.
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study concluded that a new model of reconstructed human epidermis using keratinocytes from plucked hair follicles offers a less-invasive alternative to conventional skin-derived models for skin research.
This study found that gels containing glycyrrhizic acid and aqueous Glycyrrhiza glabra extract significantly reduced underarm hair growth in terms of area, thickness, length, and number compared to their gel bases.
December 2025 in “International Journal of Pharmacology” This review highlights that iPSC-derived artificial platelets offer a promising alternative to platelet-rich plasma for regenerative medicine, with standardized manufacturing and reproducible pharmacological properties, addressing variability issues associated with donor-derived platelets and showing therapeutic potential in preclinical models of osteoarthritis.
September 2023 in “Bangladesh Journal of Neurosurgery” This case report shares that a 25-year-old man with cerebral arteriovenous malformation was successfully treated with stereotactic radiosurgery in Bangladesh, achieving complete obliteration of the AVM without significant clinical symptoms.
January 2021 in “Middle East journal of applied sciences” This article discusses the widespread issue of zinc deficiency affecting plant, animal, and human health, and reports no new clinical results; the authors emphasize the need for adequate zinc availability in agriculture and nutrition.
Chemicals and stem cells combined have advanced regenerative medicine with few safety concerns, focusing on improving techniques and treatment effectiveness.
835 citations
,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
438 citations
,
October 2010 in “Oncogene” This review discusses the role of keratins in epithelial cell stress protection and cancer, highlighting their potential as multifunctional regulators and diagnostic markers, without presenting new research findings.
354 citations
,
February 2011 in “Genes & Development” This study found that abolishing H3K27me3 in mouse skin by targeting Ezh2 and Ezh1 affects hair follicle development and epidermal behavior, revealing functional differences between these tissues.
320 citations
,
December 2018 in “Frontiers in Immunology” This review explores how preconditioning mesenchymal stromal cells can impact their secretome's therapeutic potential in regenerative medicine, emphasizing immunomodulatory and regenerative functions, but provides no new clinical results.
173 citations
,
January 2014 in “Nature Cell Biology” This study found that Wnt signalling activates hair follicle fate in hair follicle stem cells by relieving TCF3/4–TLE-mediated repression, with β-catenin being crucial for this process.
144 citations
,
August 2019 in “Cells” This review discusses the WNT signaling pathway's involvement in human diseases and highlights recent advances in WNT-related treatments, but it presents no new research findings.
127 citations
,
January 2015 in “Journal of Biological Rhythms” This review discusses the role of the circadian clock in skin functions such as cell proliferation and UV protection and reports no new results; the authors note its potential in studying immune regulation and seasonal behaviors.
113 citations
,
March 2018 in “Biological reviews/Biological reviews of the Cambridge Philosophical Society” This review examines the adaptive value and mechanisms of seasonal coat colour moulting in birds and mammals, highlighting the challenge of camouflage mismatch and the necessity for evolutionary adaptation under climate change.
85 citations
,
May 2019 in “Journal of neuroendocrinology” This review examines the neuroendocrine mechanisms underlying seasonal changes in mammals and highlights areas needing further research, reporting no new experimental results.
77 citations
,
March 2021 in “Nature” In this study, increased corticosterone from chronic stress prolonged hair follicle stem cell quiescence in mice, inhibiting regeneration, but restoring Gas6 expression overcame this inhibition.
75 citations
,
August 2018 in “Biochemical pharmacology” This review discusses the potential of targeting the endocannabinoid system for treating skin disorders and reports no new clinical results, highlighting the need for further research.
72 citations
,
November 2012 in “PloS one” This study found that dysregulation of the folliculin-p0071 interaction may lead to changes in cell adhesion and signaling, contributing to conditions like emphysema and renal cell carcinoma.
61 citations
,
September 2016 in “NPG Asia Materials” This study developed thermo-reversible glycol chitosan hydrogels that effectively form and maintain 3D cell spheroids within one day, offering a simplified method for creating biologically realistic cultures for tissue regeneration and drug screening applications.
57 citations
,
September 2017 in “Journal of controlled release” This review discusses recent advances in using nanocarrier-loaded gels for various medical applications and reports no new clinical results, highlighting potential advantages in therapeutic strategies.
57 citations
,
February 1983 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study found that pubic skin fibroblasts respond to androgens, increasing 5α-reductase activity via an androgen receptor-mediated mechanism, suggesting its potential as a marker of androgen action in vitro.