11 citations
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September 2021 in “Journal of molecular endocrinology” This review discusses differences in ERβ signaling between rodents and humans and reports no new clinical results; the authors highlight the need for further research in humans before using ERβ agonists clinically.
3 citations
,
August 2010 in “Letters in Drug Design & Discovery”
4 citations
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October 2022 in “Evidence-based complementary and alternative medicine” This study found that Ficus carica extract enhanced fertility markers, including hormone levels and reproductive organ activity, in rats of both sexes, suggesting potential benefits for managing fertility issues.
8 citations
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January 1991 in “Soviet physics. Doklady” This article suggests that testosterone therapy might be considered if other treatments fail, but emphasizes discussing potential risks and benefits with patients before prescribing.
1 citations
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January 2016 in “Journal of Microbial & Biochemical Technology” This study found that the free androgen index (FAI) is a superior marker of hyperandrogenism in men with premature androgenetic alopecia compared to DHEAS and testosterone levels.
January 2004 in “Weiliang yuansu yu jiankang yanjiu” This study found that copper levels varied significantly by gender, while young infants had higher levels of copper, zinc, calcium, magnesium, and iron compared to older age groups.
December 2020 in “Research Square (Research Square)” This study suggests that 150 kHz electromagnetic radiation exposure may reduce follicular cysts and increase developing follicles in a rat model of polycystic ovaries without affecting hormonal levels or overall ovary morphology.
63 citations
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January 2010 in “Frontiers in Aging Neuroscience” This study found that 3alpha-diol, an androgen metabolite, improved cognitive and affective performance in aged male rats, suggesting its role in countering age-related decline in hippocampally-influenced behaviors.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that engineered high-affinity soluble CD200R agonists, including ARQ-234, showed superior efficacy in reducing immune responses in various preclinical models of inflammatory conditions, suggesting potential as a therapeutic for atopic dermatitis and other related diseases.
133 citations
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July 2006 in “International Journal of Dermatology” This study found that topical eflornithine HCl 13.9% cream effectively reduced facial hair in women, with a favorable safety profile.
65 citations
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September 2023 in “Cell Reports Medicine” This review examined the common side effects of FGFR inhibitors like erdafitinib, pemigatinib, and futibatinib, and detailed strategies for managing them, highlighting that proactive monitoring and appropriate interventions can effectively mitigate these toxicities.
35 citations
,
November 1989 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” This study found that epitestosterone acts as a weak antiandrogen by inhibiting receptor binding and 5α-reductase activity in animal models.
4 citations
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May 2023 in “Research Square (Research Square)” This study found that cephalanthine inhibited the growth of gastric cancer cells in vitro and in vivo by inducing oxidative stress and altering energy metabolism, suggesting its potential as a treatment for gastric cancer.
16 citations
,
April 2017 in “Journal of Cosmetic Dermatology” This study found that fig leaf extract significantly downregulated inflammatory and androgenic gene expression in vitro, suggesting potential topical benefits for certain skin disorders.
39 citations
,
September 2007 in “BMC developmental biology” This study found that Neuregulin3 can influence the development and differentiation of mammary glands and epidermal features in mice, potentially by inducing c-Myc and altering cell proliferation and adhesion.
28 citations
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June 2020 in “Poultry Science” This study found that injecting L- or DL-Methionine into chick embryos increased feather growth and follicle development by activating the Wnt/β-catenin signaling pathway, with no difference between the two methionine forms.
April 2026 in “Research Square” E13 fetal mouse fibroblast vesicles may help reduce scarring.
14 citations
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April 2024 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that epitestosterone, a stereoisomer of testosterone, is metabolized to 5α-dihydroepitestosterone by human 5α-reductase enzymes, which enhances its androgenic activity and reduces its antagonistic effect on testosterone-driven androgen receptor signaling.
January 2025 in “Biomedicines” In this study, female rats given high doses of testosterone showed decreased endometrial thickness and lower mRNA levels of components in the LIF signalling pathway, indicating that excessive testosterone may negatively impact endometrial receptivity and potentially affect fertility.
42 citations
,
May 2003 in “Mini-reviews in Medicinal Chemistry” This study found that newly synthesized steroidal trienones demonstrated stronger 5α-reductase inhibitory activity compared to dienones in various biological models, suggesting potential for developing enhanced antiandrogenic drugs.
66 citations
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April 1995 in “The journal of cell biology/The Journal of cell biology” In this study, researchers reported that a keratinocyte growth factor-Ig fusion protein could specifically detect and localize KGFRs in epithelial tissues, suggesting a method for histochemical detection of growth factor receptors.
216 citations
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June 2015 in “PLANT PHYSIOLOGY” This study found that OsPHR3 overexpression in rice led to significant tolerance to low-phosphorus stress and normal growth under normal conditions, suggesting its potential for improving phosphorus uptake efficiency.
August 2019 in “Carolina Digital Repository (University of North Carolina at Chapel Hill)” This study indicates that MAGE-11 modulates androgen receptor transcriptional activity through F-box interactions, independent of the activation function 2 pathway, revealing a novel mechanism for androgen receptor regulation.
4 citations
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September 2010 in “Medical Hypotheses” July 2024 in “Reactions Weekly” 2 citations
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July 2024 in “Materials Today Communications” In this study, an injectable alginate hydrogel with Fibronectin3 was developed, demonstrating high biocompatibility and ability to enhance wound healing in mice, suggesting promise for clinical application in treating irregular wounds.
3 citations
,
July 2023 in “Cells” This study found that topical application of recombinant human MG53 protein mitigated nitrogen mustard-induced skin injuries in mice by preserving epidermal integrity and hair follicle structure.
February 2019 in “Trace elements and electrolytes” This study found that women with chronic telogen effluvium had significantly lower levels of zinc, copper, and ferritin in their serum compared to healthy controls.
August 2009 in “한국실험동물학회 학술발표대회 논문집” Fermented Rhus Verniciflua Stokes Extract may help hair grow in cells and mice.
June 2021 in “Archives of Advances in Biosciences” This study suggests that finasteride at doses of 5 mg/kg BW or higher may adversely affect spermatogenesis and male fertility in NMRI mice.