November 2006 in “Yafteh” This study found that an herbal drug reduced the duration of telogen effluvium more effectively than minoxidil in patients.
1 citations
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March 2009 in “The Journal of Urology” This review discusses trials on therapies for benign prostatic hyperplasia and reports that combination treatment is more effective than monotherapy for symptom relief and slowing disease progression in men with moderate to severe symptoms and enlarged prostate glands.
1 citations
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January 2010 This study found that using minoxidil 2% as a mesotherapy injection showed more significant improvement in treating androgenetic alopecia in female patients than topical application.
10 citations
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March 2022 in “Frontiers in Oncology” This study found that the overexpression of the lncRNA HOTTIP in glioma cells increased resistance to the chemotherapy drug temozolomide, suggesting a key role for miR-10b and EMT processes in this resistance.
6 citations
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June 1983 in “Cancer” This study found that a chemotherapy regimen combining CMFVP and ACP treatments for unresectable metastatic breast cancer yielded a 66.7% overall response rate, with premenopausal women responding more favorably than postmenopausal women.
February 2006 in “PubMed” In this study, docetaxel combined with prednisone significantly extended survival by about 2.5 months in men with hormone-resistant metastatic prostate cancer compared to mitoxantrone plus prednisone, despite the potential for severe adverse effects.
7 citations
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February 2021 in “Legal Medicine” This study reports two cases of fatal metformin intoxication with hair concentrations significantly higher than those in subjects under treatment, marking the first use of hair analysis for such cases.
24 citations
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December 2012 in “Behavioural Brain Research” This study found that altering Allopregnanolone levels in neonatal rats affects their adult exploratory and anxiety-like behaviors and impairs avoidance learning.
October 1977 in “Munich Personal RePEc Archive (Ludwig Maximilian University of Munich)” This study found that telogen effluvium occurred in two subjects taking 500 mg of mefloquine weekly, and gastrointestinal intolerance was observed at higher doses in additional acute studies.
52 citations
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April 2002 in “Brain Research” This study found that in rats, finasteride significantly reduced allopregnanolone in the cortex and increased both the rise and duration of dopamine levels in the prefrontal cortex in response to stress and anxiogenic stimuli.
May 2022 in “Indian Journal of Pharmacology” This case report highlights a rare instance of valproate-induced hypertensive urgency in a 2-year-old girl, with improvement after stopping the medication.
July 2024 in “Chemical Engineering Journal” A new microneedle system with minoxidil nanoparticles effectively promotes hair regrowth with fewer side effects.
5 citations
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October 1993 in “International Journal of Dermatology” This study found that 2% minoxidil led to moderate to dense hair growth in 80% of Middle-Eastern men treated for 48 weeks with early androgenic alopecia.
This study found that the novel alcohol-free topical foam CG2001, combining minoxidil and finasteride, was safe and well-tolerated in Chinese males with androgenetic alopecia, with significantly lower systemic exposure to finasteride compared to oral administration, potentially reducing sexual side effects.
29 citations
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October 2009 in “Pharmacology Biochemistry and Behavior”
43 citations
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January 1977 in “Toxicology and Applied Pharmacology” In this study, minoxidil was found to have low toxicity in various animals, with specific heart lesions observed only in dogs at certain doses.
October 2017 in “Journal of Investigative Dermatology Symposium Proceedings” This study suggests that PGD2 may increase testosterone production in keratinocytes through oxidative stress pathways, with n-acetyl-cysteine blocking this effect.
December 2019 in “Arak Medical University Journal” This study found that adding 7% chamomile extract to 5% minoxidil solution reduced cutaneous side effects like itching, scaling, and erythema in men with androgenic alopecia compared to using minoxidil alone.
3 citations
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May 1994 in “Journal of Pharmacology and Experimental Therapeutics” This study found that minoxidil sulfate stimulates Cl channels, potentially depolarization-activated and outwardly rectifying, in eccrine clear cells, while minoxidil itself stimulates Ca-insensitive K currents.
15 citations
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July 2010 in “Journal of Allergy and Clinical Immunology” This study found that in mouse models, the novel NF-κB inhibitor DHMEQ improved symptoms of atopic dermatitis as effectively as tacrolimus or betamethasone.
83 citations
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July 2004 in “Pharmacology Biochemistry and Behavior” Higher 3α,5α-THP levels in the brain may reduce depression in pregnant rats.
2 citations
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August 2019 in “PubMed” This abstract reports that topical minoxidil is currently the only FDA-approved treatment for pattern hair loss in both men and women.
2 citations
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January 1984 in “Progress in neuro-psychopharmacology & biological psychiatry” This study found that benzodiazepine therapy in women with idiopathic hirsutism significantly increased sex hormone binding globulin and decreased dehydroepiandrosterone sulphate, but did not significantly affect hair growth.
April 2016 in “Journal of Investigative Dermatology” This study identified mefloquine as a potent inducer of lethal ER stress that effectively eliminated vemurafenib-resistant and sensitive melanoma cells, suggesting its potential for repurposing as a melanoma treatment.
180 citations
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July 1973 in “The New England Journal of Medicine” In this study, minoxidil effectively reduced blood pressure to near normal levels in patients with malignant or accelerated hypertension resistant to conventional treatments, offering a potential alternative to nephrectomy.
November 2023 in “Dermatology Research and Reports” This study reported that a 1% ivermectin topical cream for rosacea was stable over six months, showing no significant changes in key physical properties or microbial contamination, suggesting it may reduce chronic antibiotic use in rosacea treatment.
9 citations
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April 1970 in “Biochemical pharmacology” This study found that stilbamidine and hydroxystilbamidine can inhibit the release of specific enzymes from lysosomes and mitochondria in rabbit liver at certain concentrations, with effects similar to cortisol and chloroquine.
October 2008 in “Clin-alert” This abstract lists keywords related to various medications and therapies, but it does not provide new study results or findings.
December 2022 in “Journal of The American Academy of Dermatology” This letter highlights the lack of evidence on managing persistent alopecia induced by chemotherapy and endocrine therapy in breast cancer patients, noting that prior studies have not included endocrine therapy-induced alopecia.
19 citations
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January 2011 in “Frontiers in Endocrinology” The study found that social isolation in mice increases the sensitivity of their hippocampal synapses to ethanol's inhibitory effects on long-term potentiation, an effect preventable by finasteride.